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NIDDK Archives

Detect and defend against pathogens

Nov. 4, 2015—Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.

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Inflammation, obesity and diabetes

Oct. 29, 2015—Vanderbilt study adds to the mounting role for inflammatory signaling in obesity.

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Tolerating a transplant

Oct. 1, 2015—A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.

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How to build a basement

Sep. 9, 2015—Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer.

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Vitamin C protects blood vessel lining

Sep. 4, 2015—Dietary vitamin C may maintain healthy blood vessels in patients with inflammatory diseases.

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Origins of neuroblastoma

Aug. 12, 2015—Vanderbilt researchers are exploring how neuroblastoma tumors begin and progress, knowledge that could provide new treatments for this pediatric cancer.

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Stomach cancer cues

Aug. 6, 2015—Vanderbilt scientists have discovered a new molecular mechanism that promotes stomach cancer development, findings that could provide new opportunities for treatment.

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Study explores protein’s role in inflammation-associated cancer

Jul. 23, 2015—An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients.

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Grant to spur study of ‘brown fat’s’ metabolic mysteries

Jun. 25, 2015—Vanderbilt researchers have received a $2.15 million grant to study the amount and activity of “brown fat” in adults, with the aim of understanding its role in metabolic disease and identifying new therapeutic targets.

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New strategy to combat HIV

Jun. 12, 2015—Inhibitors of the enzyme phospholipase D1 suppress the replication of HIV-1, Vanderbilt investigators have discovered.

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A “CRISPR” way to study disease

Jun. 11, 2015—Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases.

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Team tracks how kidney responds to blood pressure meds

Apr. 30, 2015—Changes in the kidney can limit the blood pressure-lowering effects of thiazide diuretics, a new study reports.

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