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NIDDK Archives

Fat hormone’s role in zebrafish

Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

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Liver balancing act

Feb. 24, 2016—Vanderbilt researchers have defined a mechanism that limits liver cell proliferation after injury in order to preserve critical metabolic functions.

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Building intestinal brush borders

Feb. 8, 2016—Studies of the molecular complex that helps build specialized cellular surfaces could shed light on the mechanisms underlying a genetic deaf-blindness syndrome accompanied by intestinal disease.

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DISSECTing cell signaling networks

Dec. 14, 2015—Vanderbilt researchers have developed a new method to study cell signaling networks at single-cell resolution.

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Microtubules act as cellular ‘rheostat’ to control insulin secretion

Dec. 3, 2015—Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

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Fighting type 2 diabetes with FGF1

Nov. 18, 2015—The growth factor FGF1 induces the growth of new insulin-producing beta cells and may help treat type 2 diabetes.

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Immune system a must for kidney repair

Nov. 12, 2015—A signaling protein that is essential for recovery from acute kidney injury works by increasing the population of tissue-repairing immune cells.

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Detect and defend against pathogens

Nov. 4, 2015—Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.

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Inflammation, obesity and diabetes

Oct. 29, 2015—Vanderbilt study adds to the mounting role for inflammatory signaling in obesity.

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Tolerating a transplant

Oct. 1, 2015—A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.

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How to build a basement

Sep. 9, 2015—Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer.

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Vitamin C protects blood vessel lining

Sep. 4, 2015—Dietary vitamin C may maintain healthy blood vessels in patients with inflammatory diseases.

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