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NIDDK Archives

Colon cancer’s cellular crossroads

Mar. 16, 2012—New information about signaling pathways involved in colorectal cancer could aid in assessing prognosis and identifying new therapeutic targets for the disease.

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Digestive disease research bolstered by grant renewal

Jan. 20, 2012—The Vanderbilt Digestive Disease Research Center celebrates its 10th anniversary this year with a second five-year renewal of its federal research grant.

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Pumping up the pancreas in pregnancy

Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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Meds’ benefits differ in dialysis patients

Jan. 5, 2012—About half of kidney patients will die from heart disease within five years of starting dialysis, yet patients with kidney failure are rarely included in heart disease research. Jorge Gamboa, M.D., T. Alp Ikizler, M.D., and Nancy Brown, M.D., completed a small study that suggests a more personalized approach to selecting medication for heart disease...

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Young stem cells counter kidney aging

Dec. 15, 2011—Young bone marrow cells alleviate aging-related kidney changes in mice.

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Pathway to colon cancer progression

Dec. 1, 2011—Molecular players involved in colon cancer progression could provide new biomarkers to indicate invasiveness and prognosis.

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Protein family key to aging linked to suppressing tumors

Oct. 28, 2011—The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health.

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Growth factor boosts beta cells

Oct. 21, 2011—A growth factor may help grow transplantation-quality pancreas cells for treating diabetes.

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Initiative to help ‘translate’ diabetes research advances

Oct. 21, 2011—The new Center for Diabetes Translation Research will translate scientific breakthroughs into practices that can be applied in the doctor’s office and the patient’s home.

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Diversity key in antibody repertoire

Oct. 7, 2011—Antibodies to the 2009 H1N1 influenza strain reveal new insights into how antibody diversity forms and functions, with possible implications for designing flu vaccines.

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Heart protein may be target for colon cancer therapies

Oct. 7, 2011—A protein critical in heart development may also play a part in colon cancer progression.

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