NIDDK

  • Human kidney cross section on scientific background. 3d illustration

    ‘Pre-conditioning’ restores immune tolerance

    A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered. Read More

    Sep. 16, 2021

  • Vanderbilt University

    Motor protein linked to intestinal cell differentiation

    The motor protein MYO5B, a cause of the congenital intestinal disorder microvillus inclusion disease, does more than move cellular cargo, Vanderbilt researchers have discovered. Read More

    Aug. 5, 2021

  • Human kidney cross section on scientific background. 3d illustration

    Gene expression in diabetic nephropathy

    Vanderbilt researchers are looking to mRNA populations in podocytes — kidney cells that help filter blood — to help identify potential targets for treating diabetic kidney disease. Read More

    Aug. 5, 2021

  • Vanderbilt University

    Beta cell regeneration

    Vanderbilt researchers dissected the complex microenvironment of the pancreatic islet to discover the signals that drive beta cell regeneration — as a possible treatment for diabetes. Read More

    May. 20, 2021

  • Human kidney cross section on scientific background. 3d illustration

    New insights into kidney development

    Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function. Read More

    Apr. 15, 2021

  • Vanderbilt University

    Study revises understanding of cancer metabolism

    Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years. Read More

    Apr. 7, 2021

  • fat cells

    HIV, diabetes and immune cells in fat

    In HIV-positive individuals with diabetes, immune cells in fat are more proinflammatory and cytotoxic and may represent a therapeutic target for diabetes. Read More

    Mar. 18, 2021

  • Vanderbilt University

    Probiotic protection

    A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease. Read More

    Mar. 4, 2021

  • Vanderbilt University

    Targeting glucagon action in diabetes

    Disrupting the action of glucagon — a pancreatic hormone that works to raise blood glucose — restores functional insulin-producing cells in mouse models of type 1 diabetes and may be a promising treatment strategy. Read More

    Mar. 4, 2021

  • Closeup shot of an African American man testing his blood sugar level

    Gene variant and glucose metabolism

    Genetic variation that impacts glucose- and insulin-related signaling affects responses to type 2 diabetes treatments and warrants further study. Read More

    Feb. 18, 2021

  • Vanderbilt University

    Gene network for leukemia factor

    A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment. Read More

    Feb. 4, 2021

  • diabetes

    A cohort for type 2 diabetes studies

    A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs. Read More

    Nov. 17, 2020

  • Overweight or obese family in the park

    New treatment for a rare obesity

    Diabetes drugs known as GLP-1 receptor agonists, such as exenatide (Byetta), are a promising and safe treatment for a rare form of obesity. Read More

    Nov. 3, 2020

  • The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder).

    Preserving gut mucus architecture

    A new method that keeps microbes and gut cells together will be useful for studies of complex host-microbe interactions and for analysis of clinical specimens. Read More

    Oct. 20, 2020

  • Vanderbilt University

    Clue to diabetic kidney disease

    Vanderbilt researchers have identified a signaling pathway that promotes kidney fibrosis in patients with diabetes — and that could be targeted with an existing approved medication. Read More

    Oct. 5, 2020

  • Vanderbilt University

    Rational vaccine design

    Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read More

    Sep. 22, 2020

  • Pneumonia bacteria

    Probing pathogen antibiotic resistance

    Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics. Read More

    Sep. 17, 2020

  • birth-control

    The importance of estrogen cycles

    Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer. Read More

    Aug. 6, 2020

  • plant based milk soy

    Soy food, metabolism and the microbiome

    Consumption of soy foods may shape the microbiome and protect against hypertension only in individuals with soy-responsive microbiota, Vanderbilt researchers have discovered. Read More

    Jul. 27, 2020

  • Helicobacter Pylori bacterium, medical illustration pathogenic microorganism in human stomach

    Stomach bug hit-and-run

    The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate. Read More

    Jul. 23, 2020