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NIDDK Archives

Single-cell study of tumor samples

Oct. 26, 2016—A new method for analyzing cells in fixed biopsy tissues from patients by guide personalized treatment strategies for cancer.

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Motoring to the tips of the brush border

Oct. 6, 2016—New findings implicate a motor protein in the assembly of the brush border in the intestines and kidneys – a specialized surface that is critical for healthy organ function.

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Targeting norovirus “noxiousness”

Sep. 28, 2016—New discoveries will guide efforts to develop vaccines or antiviral agents for norovirus, the most common cause of infectious diarrhea.

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Study shows excess dietary zinc worsens C. diff infection

Sep. 26, 2016—Too much dietary zinc increases susceptibility to infection by Clostridium difficile — “C. diff” — the most common cause of hospital-acquired infections.

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Restore T cells to fight leukemia

Sep. 14, 2016—Modulation of T cell metabolism thus may represent a new therapeutic avenue for leukemia patients.

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Proliferative capacity of neuroblastoma

Aug. 31, 2016—The sphere-forming frequency of neuroblastoma cells is a measure of their proliferative capacity and could help guide treatment strategies for neuroblastoma.

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It takes two to tango: beta cell development

Jun. 23, 2016—Defining the genes required for the function of insulin-producing beta cells is crucial for ongoing efforts to develop a cell-based therapy for diabetes.

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Fat hormone’s role in zebrafish

Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

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Liver balancing act

Feb. 24, 2016—Vanderbilt researchers have defined a mechanism that limits liver cell proliferation after injury in order to preserve critical metabolic functions.

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Building intestinal brush borders

Feb. 8, 2016—Studies of the molecular complex that helps build specialized cellular surfaces could shed light on the mechanisms underlying a genetic deaf-blindness syndrome accompanied by intestinal disease.

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DISSECTing cell signaling networks

Dec. 14, 2015—Vanderbilt researchers have developed a new method to study cell signaling networks at single-cell resolution.

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Microtubules act as cellular ‘rheostat’ to control insulin secretion

Dec. 3, 2015—Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

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