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NIDDK Archives

VUMC team’s discovery could lead to new diabetes treatment

Jun. 15, 2017—High circulating glucose, the hallmark of diabetes, is linked to the disease’s most serious complications including heart disease, kidney failure, blindness and amputation. Diabetes is the sixth leading cause of death and costs the nation an estimated $322 billion a year. Restoring the action of insulin has been the traditional treatment route. Insulin, a hormone...

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PET imaging to predict tumor response

Jun. 14, 2017—A PET probe that detects the amino acid glutamine predicts whether tumors respond to certain targeted therapies in preclinical animal models.

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Flip side of gut protection

Jun. 9, 2017—Vanderbilt investigators report that dysregulation of certain immune cells in the intestines may lead to inflammation and disease.

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NIDDK renews Vanderbilt’s diabetes research grant

Jun. 8, 2017—The Vanderbilt Diabetes Research and Training Center (VDRTC) is celebrating its 44th year of operation with a five-year competitive renewal of its $9 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH).

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EETs contribute to insulin sensitivity

May. 11, 2017—Interventions that increase circulating levels of compounds called EETs may improve insulin sensitivity and treat hypertension.

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Protein structure may aid in treating Alzheimer’s disease

Apr. 27, 2017—A new protein structure may guide the development of Alzheimer's therapeutics.

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Blocking neuroblastoma cell growth

Mar. 22, 2017—An inhibitor of cell metabolism may be a good therapeutic target for neuroblastoma, which accounts for about 15 percent of pediatric cancer-related deaths.

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New target for colorectal cancer

Mar. 17, 2017—Vanderbilt investigators have discovered that activated epidermal growth factor receptor may be a target for therapies to prevent colorectal cancer development.

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Improving therapies for GI tumors

Feb. 20, 2017—A signaling protein overexpressed in upper gastrointestinal cancers is an attractive therapeutic target.

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Dementia linked to diet

Feb. 7, 2017—Some memory deficits observed in Alzheimer’s disease may be due to co-morbid illnesses – not the disease itself – and may be reversed by lifestyle changes or pharmacologic interventions.

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New target for chronic infection

Feb. 2, 2017—An enzyme in macrophage immune cells may be a good target for treating chronic infections, Vanderbilt researchers have discovered.

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Flu vaccine response in older adults

Jan. 25, 2017—High dose flu vaccine boosts the immune response in older adults by increasing activation of certain immune cells.

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