NIGMS
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Number of minority trainees on rise, but not minority faculty
Vanderbilt investigators examined the entire training pathway of potential biomedical research faculty and found two key points of loss: during undergraduate education and in transition from postdoctoral fellowship to tenure-track faculty. Read MoreJan 25, 2018
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HDL and kidney injury after surgery
Higher concentrations of high-density lipoproteins — HDL, the “good” cholesterol — may be protective against acute kidney injury after cardiac surgery, Vanderbilt researchers have discovered. Read MoreJan 17, 2018
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Lighting up iron levels
A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease. Read MoreJan 11, 2018
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Asthma study may point to potential new therapeutic approach
New findings from Vanderbilt suggest that blocking the migration of cells involved in asthma may represent a new approach for treating the respiratory condition. Read MoreJan 4, 2018
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DNA damage repair: molecular insights
Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer. Read MoreDec 5, 2017
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Lineage tracing in the gut
Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop. Read MoreNov 30, 2017
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A lipid’s role in cell division
Lipids in the plasma membrane regulate the position of the contractile ring that is required for cell division, Vanderbilt researchers have discovered. Read MoreNov 10, 2017
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Advanced imaging tools reveal architecture of cell division machinery
Using super-resolution microscopy tools in the Nikon Center of Excellence, Vanderbilt investigators have determined the molecular architecture of the contractile ring machinery that functions during cell division — a process that is essential for life. Read MoreNov 9, 2017
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A switch for autoimmunity
Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies. Read MoreOct 12, 2017
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Novel insights to antibiotic targets
New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines. Read MoreSep 29, 2017
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An immune regulator of addiction
Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role. Read MoreAug 4, 2017
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Altered metabolism and disease
Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone. Read MoreJul 25, 2017
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Probing the genetics of autoimmunity
Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets. Read MoreJul 21, 2017
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NOTCH1 role in heart development
The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition. Read MoreJul 3, 2017
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Genetics of lung cancer survival
Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans. Read MoreJun 29, 2017
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Repriming replication roadblocks
New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away. Read MoreJun 12, 2017
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Protein structure may aid in treating Alzheimer’s disease
A new protein structure may guide the development of Alzheimer's therapeutics. Read MoreApr 27, 2017
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A molecular clue to longevity
In budding yeast, accumulation of a certain type of RNA in the nucleus increased life span, offering a new clue to longevity. Read MoreMar 31, 2017
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A target to heal tiny lungs
The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth. Read MoreFeb 23, 2017
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Pathology of septic shock
The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection. Read MoreFeb 8, 2017