NIGMS Archives
Analyzing single-cell landscapes
Nov. 30, 2018—Qi Liu, PhD, Ken Lau, PhD, and colleagues have developed a new tool, sc-UniFrac, to quantify diverse cell types in single-cell studies.
Investigators find that bile acids reduce cocaine reward
Aug. 30, 2018—The discovery that high levels of bile acids appear to blunt cravings for cocaine could lead to new treatments for addiction.
New staph virulence factor
Jun. 28, 2018—The new factor, an enzyme involved in host-pathogen interactions, may be a viable target for treating staph infections.
Novel infection fighter
Jun. 13, 2018—A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.
Confronting TB resistance
Jun. 11, 2018—Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis.
A “public” target for HIV
Jun. 8, 2018—Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus.
Putting the brakes on sepsis
May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.
Toxin floats on lipid rafts
Apr. 23, 2018—The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells.
How the skin protects
Apr. 19, 2018—Treatments for common skin conditions such as atopic dermatitis may be improved by understanding the enzymes responsible for forming the skin’s water-tight barrier.
New view of the heartbeat
Apr. 6, 2018—Structural views of the proteins that regulate the heartbeat may help improve existing treatments for cardiac arrhythmias.
Lung diseases share molecular signature
Apr. 5, 2018—Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.
What protein is that?
Mar. 28, 2018—An improved technology enables high-throughput protein identification in imaging mass spectrometry, aiding proteomics research.