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NIGMS Archives

Microtubules act as cellular ‘rheostat’ to control insulin secretion

Dec. 3, 2015—Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

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Healing without scarring

Oct. 16, 2015—Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

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The yin and yang of COX-2

Oct. 2, 2015—New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

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Tolerating a transplant

Oct. 1, 2015—A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.

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Data diving for health

Sep. 23, 2015—To most effectively use electronic health records for research, investigators should query multiple components of the record to identify patients with specific diseases.

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Anticancer olive compounds

Jul. 27, 2015—Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet.

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Drug signaling networks

Jul. 15, 2015—Vanderbilt investigators have developed a new algorithm to understand the networks of signaling molecules that control drug action.

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Hhex on cancer

Jul. 13, 2015—A new mouse model demonstrates that the Hhex gene – which is linked to blood cancers – is critical for normal blood cell production.

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A view of brain function in disease

Jun. 16, 2015—Vanderbilt investigators report the first use of a specialized type of MRI to study the hippocampus in patients with schizophrenia.

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Boosting cell-based heart repair

May. 15, 2015—A metabolic change in adult stem cells makes them less “fit” for regenerative heart therapies, suggesting that strategies to prevent this response may boost the therapeutic usefulness of the cells.

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Neurofibromin fine-tunes bone growth

May. 6, 2015—The protein neurofibromin acts as a brake in a signaling pathway that is important in bone development, Vanderbilt researchers have discovered.

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New player in neuronal communication

May. 1, 2015—Vanderbilt researchers have discovered a novel mechanism for the development of dendritic spines – sites of nerve cell communication.

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