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NIGMS Archives

Lineage tracing in the gut

Nov. 30, 2017—Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop.

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A lipid’s role in cell division

Nov. 10, 2017—Lipids in the plasma membrane regulate the position of the contractile ring that is required for cell division, Vanderbilt researchers have discovered.

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Advanced imaging tools reveal architecture of cell division machinery

Nov. 9, 2017—Using super-resolution microscopy tools in the Nikon Center of Excellence, Vanderbilt investigators have determined the molecular architecture of the contractile ring machinery that functions during cell division — a process that is essential for life.

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A switch for autoimmunity

Oct. 12, 2017—Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.

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Novel insights to antibiotic targets

Sep. 29, 2017—New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

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An immune regulator of addiction

Aug. 4, 2017—Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.

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Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Probing the genetics of autoimmunity

Jul. 21, 2017—Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets.

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NOTCH1 role in heart development

Jul. 3, 2017—The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.

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Genetics of lung cancer survival

Jun. 29, 2017—Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans.

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Repriming replication roadblocks

Jun. 12, 2017—New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.

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Protein structure may aid in treating Alzheimer’s disease

Apr. 27, 2017—A new protein structure may guide the development of Alzheimer's therapeutics.

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