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NIGMS Archives

Immune defenses in asthma

Apr. 5, 2016—Vanderbilt researchers show that a certain factor negatively impacts the first-line responder cells in the lungs, providing one explanation for why patients with asthma are at greater risk for invasive bacterial disease.

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Health and Medicine Reporter Research


A clue to cell cleavage

Mar. 7, 2016—Actin and microtubule cytoskeletons are coordinated during cytokinesis – the process that separates one cell into two and is linked to events underlying cancer.

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Dynamics of a drug resistance transporter

Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.

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Findings offer new insight on how cell division proteins work

Jan. 28, 2016—A family of proteins with critical roles in cell division, synaptic transmission and cell migration don’t all function the way scientists thought they did, according to two new studies led by Vanderbilt researchers.

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Health and Medicine Healthcare Solutions Reporter Research


Platelet protein modification

Jan. 13, 2016—Vanderbilt investigators have identified a new biomarker to assess platelet function.

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Immune tolerance in endothelial cells

Jan. 7, 2016—Inducing “tolerance” to bacterial toxins in the endothelial cells that line blood vessels may offer a new approach for preventing the negative consequences of sepsis.

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Microtubules act as cellular ‘rheostat’ to control insulin secretion

Dec. 3, 2015—Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

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Healing without scarring

Oct. 16, 2015—Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

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The yin and yang of COX-2

Oct. 2, 2015—New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

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Tolerating a transplant

Oct. 1, 2015—A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.

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Data diving for health

Sep. 23, 2015—To most effectively use electronic health records for research, investigators should query multiple components of the record to identify patients with specific diseases.

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Anticancer olive compounds

Jul. 27, 2015—Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet.

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Health and Medicine Reporter Research


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