NIGMS Archives
A target to heal tiny lungs
Feb. 23, 2017—The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth.
Pathology of septic shock
Feb. 8, 2017—The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.
Bacterial signaling systems
Feb. 3, 2017—Vanderbilt researchers have identified a unique example of communication between bacterial signaling systems, which may have relevance for antibiotic resistance.
New target for chronic infection
Feb. 2, 2017—An enzyme in macrophage immune cells may be a good target for treating chronic infections, Vanderbilt researchers have discovered.
Improving vaccine formulations
Jan. 20, 2017—The compound MPLA is an attractive vaccine component, designed to elicit a robust immune response.
Faster (cheaper) method for making big bioactive ring molecules
Dec. 12, 2016—A pair of Vanderbilt chemists have developed a faster, cheaper method for synthesizing ring molecules called cyclic depsipeptides found in antibiotics, anti-retrovirals and pesticides.
Single-cell analysis of solid tumors
Dec. 12, 2016—A new method will make it possible to study solid tumors and healthy tissues using mass cytometry.
Making human beta cells reproduce
Dec. 8, 2016—A new method developed at Vanderbilt will speed the search for potential therapeutics for diabetes: compounds that stimulate the replication of insulin-producing beta cells.
Plasmin prevents muscle ‘hardening’ after injury: study
Dec. 8, 2016—Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.
Targeting the “un-targetable”
Nov. 18, 2016—A novel drug that targets the protein RSK blocked aggressive breast cancers from metastasizing in an animal model.
Stem cells promote tolerance
Nov. 17, 2016—Blood-forming stem cells play a role in immune tolerance and acceptance of organ transplants, Vanderbilt researchers have discovered.
Protein structure and epilepsy severity
Nov. 10, 2016—Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy.