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NIGMS Archives

A target to heal tiny lungs

Feb. 23, 2017—The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth.

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Pathology of septic shock

Feb. 8, 2017—The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.

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Bacterial signaling systems

Feb. 3, 2017—Vanderbilt researchers have identified a unique example of communication between bacterial signaling systems, which may have relevance for antibiotic resistance.

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New target for chronic infection

Feb. 2, 2017—An enzyme in macrophage immune cells may be a good target for treating chronic infections, Vanderbilt researchers have discovered.

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Improving vaccine formulations

Jan. 20, 2017—The compound MPLA is an attractive vaccine component, designed to elicit a robust immune response.

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Faster (cheaper) method for making big bioactive ring molecules

Dec. 12, 2016—A pair of Vanderbilt chemists have developed a faster, cheaper method for synthesizing ring molecules called cyclic depsipeptides found in antibiotics, anti-retrovirals and pesticides.

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Single-cell analysis of solid tumors

Dec. 12, 2016—A new method will make it possible to study solid tumors and healthy tissues using mass cytometry.

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Making human beta cells reproduce

Dec. 8, 2016—A new method developed at Vanderbilt will speed the search for potential therapeutics for diabetes: compounds that stimulate the replication of insulin-producing beta cells.

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Plasmin prevents muscle ‘hardening’ after injury: study

Dec. 8, 2016—Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.

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Targeting the “un-targetable”

Nov. 18, 2016—A novel drug that targets the protein RSK blocked aggressive breast cancers from metastasizing in an animal model.

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Stem cells promote tolerance

Nov. 17, 2016—Blood-forming stem cells play a role in immune tolerance and acceptance of organ transplants, Vanderbilt researchers have discovered.

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Protein structure and epilepsy severity

Nov. 10, 2016—Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy.

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