NIGMS

David Cortez and colleagues have discovered a new DNA repair mechanism. Read More

Qi Liu, PhD, Ken Lau, PhD, and colleagues have developed a new tool, sc-UniFrac, to quantify diverse cell types in single-cell studies. Read More

The discovery that high levels of bile acids appear to blunt cravings for cocaine could lead to new treatments for addiction. Read More

The new factor, an enzyme involved in host-pathogen interactions, may be a viable target for treating staph infections. Read More

A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections. Read More

Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis. Read More

Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus. Read More

An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection. Read More

The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells. Read More

Treatments for common skin conditions such as atopic dermatitis may be improved by understanding the enzymes responsible for forming the skin’s water-tight barrier. Read More

Structural views of the proteins that regulate the heartbeat may help improve existing treatments for cardiac arrhythmias. Read More

Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention. Read More

An improved technology enables high-throughput protein identification in imaging mass spectrometry, aiding proteomics research. Read More

A new integrated imaging approach makes it possible to probe the molecules involved in invasive infections and can be broadly applied to any health or disease state. Read More

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders. Read More

Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia. Read More

Understanding the specialized environment where stem cells reside is important for developing stem-cell based regenerative therapies. Read More

Vanderbilt investigators have discovered a role for immune system T cells in slowing the decline in skeletal muscle function in patients with Duchenne muscular dystrophy. Read More

Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines. Read More

Vanderbilt researchers have discovered imaging features associated with increased risk for aggressive meningiomas (tumors of the brain membranes) that could help guide surgical planning and patient counseling. Read More