NIDDK

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion. Read More

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine. Read More

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation. Read More

Vanderbilt University researchers have discovered how intestinal cells build the "brush border" -- a specialized surface structure that is critical for absorbing nutrients and defending against pathogens. Read More

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis. Read More

The extracellular matrix that surrounds cells plays a role in the development of insulin resistance. Read More

Smooth muscle cells that line the aorta differ in development but not in the adult, a finding that has implications for understanding aortic development and disease. Read More

Obesity causes peripheral immune cells to move to the brain, where they may contribute to inflammation and the pathophysiology of obesity. Read More

Targeting the production of molecules that promote tumor blood vessel development offers a new path for treating lung cancer. Read More

It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity. Read More

by Denise Anthony (iStock) A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast?… Read More

A protein kinase linked to inflammation and tumor development may be a good target for gastric cancer therapies. Read More

Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling. Read More

The hormone relaxin may offer a novel approach for treating diet-induced insulin resistance. Read More

Molecular characterization of pre-cancerous changes in cells lining the stomach could point to lesions with a greater risk of progression to cancer. Read More

A new in vitro system will allow investigators to explore how immune system T cells develop specialized functions. Read More

A newly identified factor regulates blood vessel growth in colorectal tumors and could be a promising target for cancer therapies. Read More

A noninvasive test can be used to identify the presence of Helicobacter pylori and evaluate its virulence, which will be useful in areas with high rates of H. pylori-associated gastric cancer. Read More

A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target. Read More

A high-salt diet worsens the carcinogenic effects of Helicobacter pylori, a bacterium that colonizes the stomachs of half of the world’s population. Read More