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NIDDK

Matrix remodeling and insulin resistance

Apr. 10, 2014—The extracellular matrix that surrounds cells plays a role in the development of insulin resistance.

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Development and disease in the aorta

Apr. 2, 2014—Smooth muscle cells that line the aorta differ in development but not in the adult, a finding that has implications for understanding aortic development and disease.

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Obesity sends immune cells to the brain

Feb. 12, 2014—Obesity causes peripheral immune cells to move to the brain, where they may contribute to inflammation and the pathophysiology of obesity.

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New direction for treating lung cancer

Feb. 7, 2014—Targeting the production of molecules that promote tumor blood vessel development offers a new path for treating lung cancer.

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Is healthy obesity possible?

Jan. 29, 2014—It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity.

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Human and Helicobacter co-evolution

Jan. 23, 2014—by Denise Anthony A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast? The answer is disruption of co-evolution...

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Therapeutic target for gastric cancer

Dec. 12, 2013—A protein kinase linked to inflammation and tumor development may be a good target for gastric cancer therapies.

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Neurotransmitter’s role in bone balance

Nov. 7, 2013—Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling.

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Relaxin combats insulin resistance

Oct. 16, 2013—The hormone relaxin may offer a novel approach for treating diet-induced insulin resistance.

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Cell changes en route to stomach cancer

Sep. 26, 2013—Molecular characterization of pre-cancerous changes in cells lining the stomach could point to lesions with a greater risk of progression to cancer.

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Probing intestinal immune cell roles

Aug. 28, 2013—A new in vitro system will allow investigators to explore how immune system T cells develop specialized functions.

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Tumor factor spurs blood vessel growth

Aug. 26, 2013—A newly identified factor regulates blood vessel growth in colorectal tumors and could be a promising target for cancer therapies.

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