NIDDK

Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles. Read More

A drug that targets multiple pathogenic steps in diabetic retinopathy may be an ideal therapeutic strategy for the disease, Vanderbilt researchers report. Read More

Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis. Read More

The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes. Read More

Structural details of a protein that is essential to normal brain function could improve treatments for epilepsy and other seizure disorders. Read More

Researchers at four institutions, including Vanderbilt, have been awarded a five-year, $9.4 million federal grant to tackle undiagnosed congenital diarrheas caused by a single gene mutation. Read More

Immune cells that produce an anti-inflammatory factor are enriched in fat tissue around the heart and may be good targets to improve heart attack outcomes. Read More

New findings establish a role for the pro-inflammatory molecule IL-33 in the early development of antibody-producing B cells. Read More

New research findings provide insight into the detrimental events that develop in response to H. pylori infection. Read More

An inexpensive generic drug once used to prevent gastrointestinal ulcers in people taking daily NSAIDs protects against C. diff infection in mice. Read More

Live cell imaging studies have revealed that microvilli — finger-like protrusions on the surface of epithelial cells — move and collide as they form the brush border. Read More

Vanderbilt investigators demonstrated that intestinal cells promote beneficial microbe behavior — the findings support developing microbiota-based therapies for intestinal health. Read More

Inflammation synergizes with a cell’s intrinsic genetic program to promote the development of pancreatic cancer. Read More

Engineered bacteria that produce beneficial compounds — and that could potentially be administered in foods like yogurt — may be a future treatment for obesity and other chronic diseases. Read More

Understanding the roles of various immune cells that reside in the gut lining could shed light on inflammatory bowel diseases. Read More

Microtubules, part of the cell's cytoskeleton, regulate the secretion of insulin, suggesting that they may be a new target for treating diabetes. Read More

Men are more susceptible to progressive kidney disease than women; new VUMC studies point to differences in the expression and activation of the EGF receptor. Read More

A new imaging method makes it possible to directly measure cell division and changes in metabolism in atherosclerotic plaques. Read More

Vanderbilt researchers have discovered that the gut microbiome composition modulates how dietary nutrients are metabolized, with potential downstream consequences on metabolic health. Read More

Lauren Woodard and Matthew Wilson have discovered a way to reprogram adult human kidney cells into cells similar to those that form during embryonic development, which could lead to new kidney disease treatments. Read More