NCATS

Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair. Read More

Interventions for delirium in the emergency department setting are needed to preserve patients’ long-term function and cognition, Vanderbilt investigators have found. Read More

New findings that reveal complex interactions in esophageal adenocarcinoma could lead to diagnostic, prognostic or therapeutic biomarkers. Read More

A higher abundance of certain bacterial species in the mouth appears to reduce the risk of type 2 diabetes, Vanderbilt investigators have discovered. Read More

A newly identified genetic risk factor for heart block after surgery may help guide the course of postoperative care. Read More

High dose flu vaccine boosts the immune response in older adults by increasing activation of certain immune cells. Read More

Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries. Read More

A new microfluidic device containing human cells that faithfully mimics the behavior of the blood-brain barrier is providing new insights into brain inflammation, the silent killer. Read More

Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk. Read More

Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection. Read More

A new method for analyzing cells in fixed biopsy tissues from patients by guide personalized treatment strategies for cancer. Read More

Lengthening sleep duration and reducing sleep disturbances in children with type 1 diabetes may improve diabetes outcomes and reduce parental stress. Read More

To prepare for the potential of a smallpox return, Vanderbilt researchers are isolating and studying naturally occurring antibodies from the blood of previously infected or immunized people. Read More

Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it. Read More

High levels of blood markers for vascular endothelial dysfunction were associated with longer periods of confusion in ICU patients, Vanderbilt researchers have discovered. Read More

Increased activity of the “fight or flight” nervous system contributes to obesity-associated hypertension and may be a good therapeutic target for the disease. Read More

Children with Prader-Willi Syndrome who received growth hormone treatment had cognitive advantages compared to untreated patients. Read More

A peptide molecule relaxes airway smooth muscle and may be a potential therapeutic for asthma that has become resistant to standard therapies. Read More

Many clinical trials are stopped prematurely because they fail to recruit enough study participants. Vanderbilt University Medical Center has received a five-year, $14 million grant from the National Center for Advancing Translational Sciences at the National Institutes of Health to address this. Read More

Imaging with a compound that binds to neuroendocrine cells is a safer and more effective way to detect rare neuroendocrine tumors. Read More