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NCATS Archives

EETs contribute to insulin sensitivity

May. 11, 2017—Interventions that increase circulating levels of compounds called EETs may improve insulin sensitivity and treat hypertension.

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A new mode of DNA repair

Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

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Delirium in the ED

Mar. 20, 2017—Interventions for delirium in the emergency department setting are needed to preserve patients’ long-term function and cognition, Vanderbilt investigators have found.

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Esophageal cancer complexities

Mar. 16, 2017—New findings that reveal complex interactions in esophageal adenocarcinoma could lead to diagnostic, prognostic or therapeutic biomarkers.

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Role for mouth microbes in diabetes?

Mar. 8, 2017—A higher abundance of certain bacterial species in the mouth appears to reduce the risk of type 2 diabetes, Vanderbilt investigators have discovered.

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Mutation raises heart block risk

Mar. 3, 2017—A newly identified genetic risk factor for heart block after surgery may help guide the course of postoperative care.

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Flu vaccine response in older adults

Jan. 25, 2017—High dose flu vaccine boosts the immune response in older adults by increasing activation of certain immune cells.

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Plasmin prevents muscle ‘hardening’ after injury: study

Dec. 8, 2016—Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.

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Blood-brain barrier on a chip sheds new light on “silent killer”

Dec. 6, 2016—A new microfluidic device containing human cells that faithfully mimics the behavior of the blood-brain barrier is providing new insights into brain inflammation, the silent killer.

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Reducing antidepressants’ side effects

Nov. 23, 2016—Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk.

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VUMC investigators find pathogens work together to infect host

Nov. 3, 2016—Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

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Single-cell study of tumor samples

Oct. 26, 2016—A new method for analyzing cells in fixed biopsy tissues from patients by guide personalized treatment strategies for cancer.

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