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NCATS Archives

Plasmin prevents muscle ‘hardening’ after injury: study

Dec. 8, 2016—Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.

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Blood-brain barrier on a chip sheds new light on “silent killer”

Dec. 6, 2016—A new microfluidic device containing human cells that faithfully mimics the behavior of the blood-brain barrier is providing new insights into brain inflammation, the silent killer.

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Reducing antidepressants’ side effects

Nov. 23, 2016—Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk.

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VUMC investigators find pathogens work together to infect host

Nov. 3, 2016—Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

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Single-cell study of tumor samples

Oct. 26, 2016—A new method for analyzing cells in fixed biopsy tissues from patients by guide personalized treatment strategies for cancer.

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Sleep issues in children with diabetes

Oct. 24, 2016—Lengthening sleep duration and reducing sleep disturbances in children with type 1 diabetes may improve diabetes outcomes and reduce parental stress.

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Preparing for a return of pox

Oct. 20, 2016—To prepare for the potential of a smallpox return, Vanderbilt researchers are isolating and studying naturally occurring antibodies from the blood of previously infected or immunized people.

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Research sheds light on how RSV wards off potential vaccines

Oct. 20, 2016—Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it.

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Risk factors for delirium

Sep. 13, 2016—High levels of blood markers for vascular endothelial dysfunction were associated with longer periods of confusion in ICU patients, Vanderbilt researchers have discovered.

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Nervous system’s role in hypertension

Aug. 29, 2016—Increased activity of the “fight or flight” nervous system contributes to obesity-associated hypertension and may be a good therapeutic target for the disease.

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Growth hormone for Prader-Willi

Aug. 25, 2016—Children with Prader-Willi Syndrome who received growth hormone treatment had cognitive advantages compared to untreated patients.

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In search of new asthma therapies

Aug. 15, 2016—A peptide molecule relaxes airway smooth muscle and may be a potential therapeutic for asthma that has become resistant to standard therapies.

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