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NCATS

Early detection of schizophrenia

Jun. 24, 2019—Inhibited temperament—a tendency to respond to novelty with wariness, fear or caution—may be a risk factor for schizophrenia that could be targeted for preventative interventions.

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Cardiac dysfunction in Duchenne’s

Apr. 4, 2019—Jonathan Soslow and colleagues have found more clues to why people with Duchenne muscular dystrophy are at risk for a certain kind of heart problem.

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Pain relievers a risk for C. diff?

Jan. 17, 2019—David Aronoff and colleagues report an increased risk of the serious gastrointestinal infection C. diff following the use of NSAID pain relievers.

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Breast cancer-killing RIG

Dec. 19, 2018—New research led by Rebecca Cook demonstrates that an antiviral receptor called RIG-I has potent immunogenic and therapeutic effects in breast cancer.

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A “public” target for HIV

Jun. 8, 2018—Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus.

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Records point to drug-drug interaction

May. 7, 2018—Patients who take a cholesterol-lowering statin drug while taking the antibiotic daptomycin have increased risk of developing muscle weakness or a more severe form of muscle damage.

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Gene expression in mitral valve disease

Apr. 25, 2018—A protease gene family may be new targets for treating mitral valve disease, which causes blood to flow backwards in the heart.

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“Idling” cancer cells may return

Apr. 11, 2018—Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment.

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Long QT syndrome – revealed

Mar. 12, 2018—Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

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Brain connections in schizophrenia

Mar. 9, 2018—Brain imaging studies have implicated the connection between two brain regions in the pathophysiology of schizophrenia.

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Cannabis compound reduces seizures

Feb. 26, 2018—Cannabidiol (CBD) oils reduced seizures in patients with difficult-to-treat epilepsy, Vanderbilt investigators have found.

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Muscular dystrophy clue

Feb. 9, 2018—Vanderbilt investigators have discovered a role for immune system T cells in slowing the decline in skeletal muscle function in patients with Duchenne muscular dystrophy.

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