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NCATS Archives

New clue to a devastating disease

Jan. 28, 2015—New findings suggest a previously unrecognized role for the Sox10 transcription factor in Hirschsprung’s disease, and may lead to improved diagnostic and therapeutic approaches for this disease.

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New view of dopamine heteromers

Jan. 23, 2015—Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.

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Inner ear keeps bones strong

Jan. 14, 2015—Alterations of the vestibular system - the part of our inner ear that controls balance - may contribute to bone loss related to both aging and space travel.

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Cognitive changes in ‘standing’ syndrome

Jan. 13, 2015—Patients with orthostatic intolerance – problems when standing – have cognitive changes, even when seated, compared to healthy individuals.

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Does fish oil help prevent A-fib?

Jan. 9, 2015—Growing evidence suggests that fish oil, thought to directly prevent inflammation, oxidative stress and heart disease, may have limited clinical utility.

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Atrial disease and hypertension links

Dec. 18, 2014—New findings suggest that misfolded proteins accumulate in the heart atria, particularly in patients with hypertension, and may contribute to atrial heart disease.

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Target for atherosclerosis therapies

Dec. 17, 2014—A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression.

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Vanderbilt’s neurovascular chip project moves into new phase

Nov. 18, 2014—Vanderbilt researchers will play a key role in the second phase of the federal "tissue chip for drug screening" program.

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Overactive stress response in obesity

Nov. 7, 2014—An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial.

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Biomarker for diabetic eye disease

Sep. 26, 2014—A person’s mitochondrial gene “signature” could predict risk for diabetic retinopathy and guide early intervention strategies.

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A path to sarcoidosis treatment

Sep. 25, 2014—Vanderbilt investigators identify a new therapeutic target for the inflammatory lung disease sarcoidosis.

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Bone healing therapy for NF1 fractures

Sep. 11, 2014—A combination treatment delivered to the site of fractures may improve bone healing in patients with the genetic disease neurofibromatosis type-1.

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