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NCATS Archives

Healing without scarring

Oct. 16, 2015—Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

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Brain circuitry in psychosis

Aug. 21, 2015—Functional magnetic resonance imaging has revealed faulty circuits between the thalamus – a central hub of brain activity – and other brain regions.

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Bridging the antibiotic gap

Aug. 7, 2015—Vanderbilt researchers have discovered how certain molecules with antibiotic properties are synthesized, findings that could lead to new drugs that overcome the increased antibiotic resistance in bacteria.

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Drug signaling networks

Jul. 15, 2015—Vanderbilt investigators have developed a new algorithm to understand the networks of signaling molecules that control drug action.

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A view of brain function in disease

Jun. 16, 2015—Vanderbilt investigators report the first use of a specialized type of MRI to study the hippocampus in patients with schizophrenia.

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New strategy to combat HIV

Jun. 12, 2015—Inhibitors of the enzyme phospholipase D1 suppress the replication of HIV-1, Vanderbilt investigators have discovered.

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New player in neuronal communication

May. 1, 2015—Vanderbilt researchers have discovered a novel mechanism for the development of dendritic spines – sites of nerve cell communication.

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Boosting beta cells in diabetes

Apr. 20, 2015—New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas.

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‘Stretched’ cells promote cancer

Feb. 19, 2015—Mechanical stress appears to be a critical factor in activating normal tissue-associated fibroblasts to generate cancer-associated fibroblasts.

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New clue to a devastating disease

Jan. 28, 2015—New findings suggest a previously unrecognized role for the Sox10 transcription factor in Hirschsprung’s disease, and may lead to improved diagnostic and therapeutic approaches for this disease.

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New view of dopamine heteromers

Jan. 23, 2015—Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.

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Inner ear keeps bones strong

Jan. 14, 2015—Alterations of the vestibular system - the part of our inner ear that controls balance - may contribute to bone loss related to both aging and space travel.

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