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Department of Biochemistry

DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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A switch for autoimmunity

Oct. 12, 2017—Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.

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Novel insights to antibiotic targets

Sep. 29, 2017—New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

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HDAC3 role in B-cell development

Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

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Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Study identifies protein’s role in chemotherapy resistance

Jul. 20, 2017—Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2.

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Frontiers in Biochemistry seminar series kicks off Aug. 18

Jun. 28, 2017—University of Chicago professor Chuan He will discuss “RNA Methylation in Gene Expression Regulation” from noon to 1 p.m. Aug. 18 in Light Hall, Room 2014, to kick off the Frontiers in Biochemistry seminar series for 2017-18. Talks in the series take place at noon on select Fridays during the school year, with prestigious speakers invited from around the United States.

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Repriming replication roadblocks

Jun. 12, 2017—New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.

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Oxidative stress in tumors

May. 18, 2017—Vanderbilt investigators have developed a new method for measuring oxidative stress in human tumors, which provides insight into cancer development.

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Protein structure may aid in treating Alzheimer’s disease

Apr. 27, 2017—A new protein structure may guide the development of Alzheimer's therapeutics.

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A new mode of DNA repair

Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

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Fighting fungal infections

Apr. 3, 2017—A detailed structural and functional analysis of the yeast protein that is the main target of antifungal drugs will help direct efforts to develop better treatments.

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