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Department of Biochemistry

Study identifies C. diff toxin receptor, suggests new treatment approaches

Jun. 4, 2015—Vanderbilt University investigators have identified a cellular receptor for a toxin from Clostridium difficile (“C. diff”) — the leading cause of hospital-acquired diarrhea in the United States.

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David Ong, professor of Biochemistry, emeritus, dies at 71

Apr. 28, 2015—David E. Ong, Ph.D., professor of Biochemistry, emeritus, whose contributions to research in the area of vitamin A biochemistry were recognized worldwide, died April 25. He was 71.

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Vanderbilt team first to blend high-end imaging techniques

Mar. 5, 2015—Vanderbilt University researchers have achieved the first “image fusion” of mass spectrometry and microscopy — a technical tour de force that could, among other things, dramatically improve the diagnosis and treatment of cancer.

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Center for Structural Biology symposium to feature stellar lineup

Feb. 26, 2015—The Vanderbilt University Department of Biochemistry will host a two-day symposium March 6-7 to honor the 60th birthday of Walter Chazin, Ph.D., director of the Center for Structural Biology.

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Antibiotics with anticancer potential

Feb. 25, 2015—A series of experimental antibiotics may be a good starting point for developing new anticancer drugs.

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Grant bolsters pancreatic cancer drug discovery efforts

Jan. 29, 2015—The Lustgarten Foundation has awarded a $1.5 million Research Investigator Grant to Stephen Fesik, Ph.D., professor of Biochemistry, Pharmacology and Chemistry, for research designed to discover new drugs for the treatment of pancreatic cancer.

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Genome-editing pioneer next up in Discovery Lecture series

Jan. 2, 2015—Jennifer Doudna, Ph.D., recipient of a 2015 Breakthrough Prize in Life Sciences, will deliver the next Flexner Discovery Lecture on Thursday, Jan. 8.

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VU study creates new road map for cellular activity

Sep. 4, 2014—Human cells are constructed in large part from proteins whose activity can be altered by the incorporation of oxygen in what are known as redox modifications.

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Ascano seeks to shed light on cellular stress response

Aug. 28, 2014—Ebola. Chikungunya. Influenza. What’s to be done about these headline-grabbing, debilitating, often lethal viruses?

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Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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Bypassing DNA damage

May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

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A new way to target cancer-driver Ras

Mar. 13, 2014—Vanderbilt researchers have discovered small molecules that turn off cancerous Ras signals in a new way.

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