Leigh MacMillan

An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies. Read More

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis. Read More

Worm neurons have microscopic “spines” — where nerve-to-nerve communication happens — that share features with mammalian neurons, supporting the use of worms to study spine genetics and biology. Read More

New findings establish a role for the pro-inflammatory molecule IL-33 in the early development of antibody-producing B cells. Read More

Vanderbilt scientists have identified 593 proteins that are enriched at sites of DNA duplication and chromatin packaging of newly synthesized DNA. Read More

Heather Pua, MD, PhD, one of 60 investigators to receive the 2019 NIH Director’s New Innovator Award, will explore a novel type of cell signaling by RNAs in allergic airway inflammation. Read More

By defining the clinical and genetic factors that predict treatment response, Vanderbilt investigators aim to personalize therapy for a common heart complication in preterm infants. Read More

VUMC's Eric Gamazon has received a Genomic Innovator Award from the National Human Genome Research Institute, part of the NIH. Read More

An analysis of more than 140,000 people of European ancestry has identified blood protein biomarkers associated with prostate cancer risk. Read More

A protein with important functions in astrocytes — star-shaped brain support cells — may alter neuronal excitability and contribute to seizure activity, Vanderbilt researchers report. Read More

Vanderbilt researchers have discovered that a protein called SGK1 in immune cells is activated by sodium, leading to the development of salt-sensitive hypertension. Read More

Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations. Read More

Combining immunotherapy and radiation therapy may be a powerful treatment approach for castration-resistant prostate cancer. Read More

Vanderbilt investigators demonstrated that intestinal cells promote beneficial microbe behavior — the findings support developing microbiota-based therapies for intestinal health. Read More

Engineered bacteria that produce beneficial compounds — and that could potentially be administered in foods like yogurt — may be a future treatment for obesity and other chronic diseases. Read More

Vanderbilt investigators have now discovered that, in contrast to prevailing dogma, fibroblasts are not all alike; instead, they have distinctive functions following tissue injury. Read More

Understanding the roles of various immune cells that reside in the gut lining could shed light on inflammatory bowel diseases. Read More

Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity. Read More

Meena Madhur, MD, PhD, has received a Presidential Early Career Award for Scientists and Engineers. Read More

A clinical study of a drug that may block cancer metastasis is currently enrolling patients at the Vanderbilt-Ingram Cancer Center. Read More