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Author: Leigh MacMillan

Flu vaccine response in older adults

Jan. 25, 2017—High dose flu vaccine boosts the immune response in older adults by increasing activation of certain immune cells.

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Colorectal cancer clues

Jan. 19, 2017—Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.

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Metastatic pancreatic cancer ‘reprograms’ for malignancy

Jan. 19, 2017—Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

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Midgut neuroendocrine tumor prognosis

Jan. 6, 2017—Vanderbilt investigators recommend that the presence of tumor deposits in the abdomen be included when staging midgut neuroendocrine tumors.

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Plasmin prevents muscle ‘hardening’ after injury: study

Dec. 8, 2016—Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.

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Stem cells promote tolerance

Nov. 17, 2016—Blood-forming stem cells play a role in immune tolerance and acceptance of organ transplants, Vanderbilt researchers have discovered.

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Links between immune cells and metabolism explored

Nov. 10, 2016—At the intersection of immunology and metabolism is a burgeoning new field: immunometabolism. It’s an area where Vanderbilt has exceptional strengths, said Jeffrey Rathmell, Ph.D., Cornelius Vanderbilt Professor of Immunobiology.

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Improving wound healing

Nov. 8, 2016—Vanderbilt researchers have shown that an injectable material improves wound healing and may be useful for large skin wounds such as those in patients with diabetes.

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Probing drug abuse circuitry

Nov. 4, 2016—Vanderbilt researchers have identified cocaine-induced modifications at specific neuronal connections, which could aid the development of new therapies for substance abuse disorders.

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VUMC investigators find pathogens work together to infect host

Nov. 3, 2016—Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

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Max Planck Institute’s Fässler set for next Discovery Lecture

Nov. 3, 2016—Reinhard Fässler, M.D., director of the Department of Molecular Medicine at the Max Planck Institute in Martinsried, Germany, will deliver the next Flexner Discovery Lecture on Nov. 10.

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Striking view

Oct. 27, 2016—Dylan Burnette, Ph.D., assistant professor of Cell and Developmental Biology, won 12th Place in Nikon’s Small World 2016 Photomicrography Competition for a colorful image of a dividing cancer cell.

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