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Author: Leigh MacMillan

New space bolsters infectious disease and immunology discovery

Jul. 9, 2020—The Vanderbilt Institute for Infection, Immunology and Inflammation (VI4) recently moved into its new research and administrative home.

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Keeping beta cells “fit”

Jul. 9, 2020—Vanderbilt cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression.

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Leadership in a COVID-19 world

Jun. 29, 2020—Being a biomedical scientist has served Interim Chancellor and Provost Susan R. Wente well as she’s led the university through “a rapid succession of significant decisions” since the first reports of COVID-19.

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Single mutation causes seizure disorder

Jun. 22, 2020—A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities.

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Probing DNA damage repair

Jun. 18, 2020—After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

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Robotic technology speeds arrhythmia gene classification

Jun. 12, 2020—Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions.

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C.diff captures blood cell cofactor to build defensive shield

Jun. 10, 2020—Vanderbilt University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics.

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Staph’s activation of blood clotting

Jun. 9, 2020—Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests.

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Protecting the injured kidney

Jun. 4, 2020—Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

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Team uses imaging to study ways the heart is affected by coronavirus

May. 21, 2020—Researchers are using imaging and diagnostic pathology to examine postmortem hearts donated by victims of COVID-19 to gain a better understanding of how the coronavirus that causes COVID-19 affects the heart.

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Probing innate immunity

May. 19, 2020—Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.

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The adaptable anthrax bacterium

May. 14, 2020—Vanderbilt researchers discover how anthrax bacterium defends itself against structural damage and resists the toxicity of the antimicrobial drug targocil.

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