Leigh MacMillan

An experimental coronavirus vaccine stimulated robust immune responses against SARS-CoV-2, the virus that causes COVID-19, and raised no serious safety concerns in an early-stage clinical trial. Read More

Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction. Read More

The Vanderbilt Institute for Infection, Immunology and Inflammation (VI4) recently moved into its new research and administrative home. Read More

Vanderbilt cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression. Read More

Being a biomedical scientist has served Interim Chancellor and Provost Susan R. Wente well as she’s led the university through “a rapid succession of significant decisions” since the first reports of COVID-19. Read More

A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities. Read More

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions. Read More

Vanderbilt University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics. Read More

Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests. Read More

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it. Read More

Researchers are using imaging and diagnostic pathology to examine postmortem hearts donated by victims of COVID-19 to gain a better understanding of how the coronavirus that causes COVID-19 affects the heart. Read More

Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA. Read More

Vanderbilt researchers discover how anthrax bacterium defends itself against structural damage and resists the toxicity of the antimicrobial drug targocil. Read More

John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules. Read More

Electronic health records and biobanks can be effectively combined to detect and study Mendelian diseases such as cystic fibrosis. Read More

A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections. Read More

Parents of children with autism spectrum disorders benefited from the addition of mindfulness-based stress reduction to parent-implemented behavioral interventions. Read More

Dylan Burnette and colleagues have discovered that two forms of the molecular motor protein myosin have distinct roles in regulating cell shape during cell division. Read More

New insights on influenza genome packaging could guide strategies for interfering with the virus's life cycle and ability to cause infection. Read More