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Author: Leigh MacMillan

Restricting HIV-1 infection

Sep. 1, 2017—Vanderbilt researchers are discovering ways that host proteins block HIV-1 infection, which could suggest new avenues for treatment.

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Pancreatic cancer development

Aug. 31, 2017—Elevated levels of the factor G-CSF appear to promote the development of aggressive pancreatic cancer, suggesting a new therapeutic approach for this devastating disease.

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Grants bolster research on rare neurological disorder AHC

Aug. 24, 2017—Kevin Ess, M.D., Ph.D., Gerald M. Fenichel Professor of Neurology, has received two grants from the Alternating Hemiplegia of Childhood Foundation (AHCF).

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Fatty acids and adenoma risk

Aug. 21, 2017—Vanderbilt researchers have found that red blood cell membrane fatty acid content is associated with risk of having colorectal adenomas, with omega-6 fatty acids increasing and omega-3 fatty acids decreasing risk.

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Discovery sheds light on protein key to nerve cells’ myelin sheath

Aug. 17, 2017—Genetic mutations in PMP22 (peripheral myelin protein 22) cause a variety of peripheral neuropathies, underscoring the importance of the protein to a healthy peripheral nervous system. But the precise function of PMP22, a major component of the myelin sheath that surrounds and insulates peripheral nerve cell axons, has been unclear.

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Block estrogen to treat lung disease

Aug. 17, 2017—Based on findings from Vanderbilt investigators and others, clinical trials of estrogen inhibition for pulmonary arterial hypertension have recently been approved and funded by the National Institutes of Health.

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Early drivers of gastric cancer

Aug. 8, 2017—Using bioinformatics approaches, Vanderbilt investigators have identified gene expression networks that are deregulated in mouse and human stomach cancers.

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HDAC3 role in B-cell development

Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

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Probing the genetics of autoimmunity

Jul. 21, 2017—Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets.

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Drivers of breast cancer metastasis

Jul. 20, 2017—Signaling through a complex of proteins called mTORC2 plays a role in breast cancer migration, invasion and metastasis, Vanderbilt researchers reported.

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Bile acids, microbiota and colon cancer

Jul. 5, 2017—Bile acids produced by a western diet alter the composition of the gut microbiota and promote intestinal carcinogenesis.

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Team investigates antiviral that inhibits SARS, MERS

Jun. 29, 2017—A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses, a multi-institutional team of investigators reports this week in Science Translational Medicine.

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