Leigh MacMillan

Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth. Read More

An opioid-restrictive prescribing protocol reduced the number of postoperative opioid prescriptions and the oral morphine equivalent per prescription. Read More

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered. Read More

A noninvasive MRI approach assesses breast tumor cell size and could be a useful way to evaluate early response to neoadjuvant therapy. Read More

Timothy Cover and colleagues report new insights into the sources of energy used by a bacterial “machine” linked to the pathogenesis of stomach cancer. Read More

Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation. Read More

Diffusion MRI may provide a noninvasive approach to assess nerve regeneration and distinguish successful from unsuccessful repairs earlier. Read More

Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis. Read More

A drug that targets multiple pathogenic steps in diabetic retinopathy may be an ideal therapeutic strategy for the disease, Vanderbilt researchers report. Read More

Genetic analyses suggest that high circulating HDL-cholesterol levels may increase breast cancer risk — a surprising finding since increased HDL-cholesterol is thought to be healthy. Read More

An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms. Read More

The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses. Read More

Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis. Read More

D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics. Read More

A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy. Read More

To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction. Read More

Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy. Read More

The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes. Read More

An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies. Read More

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis. Read More