Leigh MacMillan

  • Vanderbilt University

    Potential biomarker for IBD severity, cancer risk identified

    A selenium transport protein produced in the colon may be a novel biomarker for assessing disease severity and cancer risk in patients with inflammatory bowel disease. Read More

    Feb 4, 2021

  • Vanderbilt University

    Gene network for leukemia factor

    A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment. Read More

    Feb 4, 2021

  • conceptual illustration of brain with tangled scribbles running through it

    Inflammation in genetic epilepsy

    Brain inflammation links genetic and acquired epilepsy — providing new clues about epilepsy development and pointing to potential treatments. Read More

    Jan 21, 2021

  • Asian American female doctor discusses care with hospitalized young African American male patient by showing him information on a digital tablet

    Mitochondrial stress and hypertension

    Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential. Read More

    Jan 12, 2021

  • arthritis

    Microbial RNA and rheumatoid arthritis

    Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases. Read More

    Jan 11, 2021

  • Digital illustration of heart in an x-ray of a human chest

    Polymer protection for heart muscle

    Vanderbilt researchers demonstrate that the polymer P188 has promise as a therapy to prevent reperfusion injury — the cellular damage that occurs when blood flow returns after an ischemic event like a heart attack. Read More

    Dec 14, 2020

  • arthritis

    Study details early events of inflammatory response

    Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis. Read More

    Dec 10, 2020

  • diabetes

    A cohort for type 2 diabetes studies

    A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs. Read More

    Nov 17, 2020

  • Asian senior woman with cancer holds her granddaughter tightly in her lap. Grandma is wearing a headscarf and smiling. (A beautiful ethnic senior woman with cancer holds her granddaughter tightly in her lap. Grandma is wearing a headscarf

    Breast cancer treatment in older women

    A new study from Vanderbilt epidemiologists suggests that it’s time to reconsider clinical practice guidelines for the treatment of early-stage breast cancer in older women. Read More

    Nov 12, 2020

  • frog on a white background

    Frog peptides as anti-HIV microbicides

    Peptides derived from the antimicrobial peptides secreted by frogs could function as microbicides to limit HIV transmission, while sparing protective vaginal bacteria. Read More

    Nov 2, 2020

  • Vanderbilt University

    Grant helps expand VI4’s Artist-in-Residence program

    An innovative Vanderbilt program that brings together scientists and artists with the shared goal of scientific communication is set to expand with support from a three-year grant from the Burroughs Wellcome Fund. Read More

    Oct 29, 2020

  • conceptual illustration of brain with tangled scribbles running through it

    Histamine circuits in brain reward center

    Histamine — commonly associated with allergies — also has a signaling role in the brain’s reward center and may offer a novel target for treating addiction. Read More

    Oct 29, 2020

  • gene expression

    New tool to probe genetic mechanisms of disease

    Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases. Read More

    Oct 22, 2020

  • The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder).

    Preserving gut mucus architecture

    A new method that keeps microbes and gut cells together will be useful for studies of complex host-microbe interactions and for analysis of clinical specimens. Read More

    Oct 20, 2020

  • Blood vessel

    Brain blood vessel response to hypoxia

    The brain’s response to low oxygen — growth and remodeling of blood vessels — involves certain cell types and molecular pathways, Vanderbilt researchers have discovered. Read More

    Oct 15, 2020

  • Vanderbilt University

    Early steps in reovirus replication

    Conformational change in a reovirus surface protein modulate the virus’s attachment to host cells, Vanderbilt researchers have found. Read More

    Oct 6, 2020

  • thalamus

    Pinpointing brain changes in psychosis

    Specific regions of the thalamus — a central brain region — are smaller in adults with psychotic disorders and youth at risk for psychotic disorders and are associated with cognitive impairment. Read More

    Oct 1, 2020

  • Vanderbilt University

    Rational vaccine design

    Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read More

    Sep 22, 2020

  • Pneumonia bacteria

    Probing pathogen antibiotic resistance

    Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics. Read More

    Sep 17, 2020

  • electronic medical record ehr emr

    Award supports integration of genomic data, electronic health records

    Eric Gamazon, PhD, assistant professor of Medicine, has been awarded a $1.5 million grant from the National Human Genome Research Institute, part of the National Institutes of Health (NIH), to develop novel computational tools that integrate functional genomic data and electronic health records. Read More

    Sep 10, 2020