Author: Leigh MacMillan
Probing pathogen antibiotic resistance
Sep. 17, 2020—Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics.
Award supports integration of genomic data, electronic health records
Sep. 10, 2020—Eric Gamazon, PhD, assistant professor of Medicine, has been awarded a $1.5 million grant from the National Human Genome Research Institute, part of the National Institutes of Health (NIH), to develop novel computational tools that integrate functional genomic data and electronic health records.
Fibroids and birth outcomes
Sep. 8, 2020—Women with three or more uterine fibroids — non-cancerous growths — during pregnancy are more likely to have infants with reduced birthweight and may need additional surveillance.
Assembling cell power plant machinery
Sep. 3, 2020—Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.
Blocking tumor ‘signals’ and ‘fuel’
Aug. 25, 2020—Combining two drugs reduced colorectal cancer cell growth in vitro and in an animal model, suggesting the combination may be a promising treatment for patients.
Salt, immune cells and hypertension
Aug. 20, 2020—Excess dietary salt activates immune cells to induce inflammation and hypertension, supporting current recommendations for low sodium consumption.
Risk marker for repeat sinus surgery
Aug. 11, 2020—An inflammatory factor in mucus could be a biomarker of treatment-resistant chronic sinusitis used to determine which patients are at risk for repeat sinus surgery.
ID of ‘stomach flu’ culprit
Aug. 6, 2020—Identifying the norovirus genotypes associated with more severe infections in children could guide strain selection for candidate norovirus vaccines.
Appendix cancer survival in young patients varies by race: study
Aug. 6, 2020—Appendiceal cancer — cancer of the appendix — is a rare malignancy that is usually found during surgery for acute appendicitis. Although the rate of appendectomies has been stable over the last two decades, the incidence of malignant appendiceal cancer increased 232% in the United States.
Post-transplant complication
Jul. 28, 2020—Vanderbilt researchers conducted the largest analysis to date of a heart complication in children following stem cell transplant. The findings may help guide screening practices to improve outcomes.
Stomach bug hit-and-run
Jul. 23, 2020—The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate.
Cellular antiviral defenses
Jul. 23, 2020—A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.