School Of Medicine Basic Sciences
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The discovery of a ‘negative regulator’ in the brain alters understanding of brain function and potential treatment of cognitive disorders
Terunaga Nakagawa and the Vanderbilt Brain Institute discover new qualities of GSG1L, responsible for activity in the anterior thalamus. Read MoreJul 21, 2020
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Get to know Vanderbilt’s residential faculty: Professor Alyssa Hasty
As the new academic year gets underway, Vanderbilt’s faculty heads of house are revealing some things about themselves in this special portrait series. Get to know Alyssa Hasty, Cornelius Vanderbilt Chair in Molecular Physiology and Biophysics and faculty head of Murray House. Read MoreJul 17, 2020
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New tools to study bioactive lipids
Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction. Read MoreJul 14, 2020
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Keeping beta cells “fit”
Vanderbilt cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression. Read MoreJul 9, 2020
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Leadership in a COVID-19 world
Being a biomedical scientist has served Interim Chancellor and Provost Susan R. Wente well as she’s led the university through “a rapid succession of significant decisions” since the first reports of COVID-19. Read MoreJun 29, 2020
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Single mutation causes seizure disorder
A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities. Read MoreJun 22, 2020
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Probing DNA damage repair
After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read MoreJun 18, 2020
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Studying cells in reduced dimensions
Vanderbilt cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data. Read MoreJun 18, 2020
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Vanderbilt University partners with ACADIA Pharmaceuticals to develop novel treatments for central nervous system disorders
Vanderbilt University’s Warren Center for Neuroscience Drug Discovery has entered into an exclusive worldwide licensing and collaboration agreement with San Diego-based ACADIA Pharmaceuticals Inc. to develop treatments for disorders like Alzheimer’s and schizophrenia. Read MoreJun 16, 2020
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Leader in Vanderbilt drug discovery efforts, Craig Lindsley named interim editor-in-chief of ACS Pharmacology & Translational Science
Craig Lindsley, William K. Warren, Jr. Chair in Medicine and university professor of biochemistry, chemistry and pharmacology, has been named interim editor-in-chief of the journal "ACS Pharmacology & Translational Science." Read MoreJun 12, 2020
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Research probes why COVID-19 seems to spare young children
Lung disease experts at Vanderbilt University Medical Center and their colleagues have determined a key factor as to why COVID-19 appears to infect and sicken adults and older people preferentially while seeming to spare younger children. Read MoreMay 28, 2020
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Probing innate immunity
Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA. Read MoreMay 19, 2020
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New method captures early viral-host protein interactions
Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins. Read MoreMay 7, 2020
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A dual-purpose metabolic switch
John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules. Read MoreMay 5, 2020
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Ascano, Zanic named Basic Sciences Dean’s Faculty Fellows
The School of Medicine Basic Sciences has established a new Dean’s Faculty Fellows program designed to recognize the efforts of faculty in the early stages of their careers. Read MoreApr 24, 2020
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Transporter’s role in gut barrier
A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections. Read MoreApr 21, 2020
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‘Tuning’ cell shape for division
Dylan Burnette and colleagues have discovered that two forms of the molecular motor protein myosin have distinct roles in regulating cell shape during cell division. Read MoreApr 20, 2020
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Blocking stress-induced relapse
Danny Winder and colleagues are teasing apart the actions of neurotransmitter receptors in a brain region linked to anxiety and addiction, with a goal of finding treatments for substance use disorders. Read MoreApr 8, 2020
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Cellular factor helps package flu genome
New insights on influenza genome packaging could guide strategies for interfering with the virus's life cycle and ability to cause infection. Read MoreApr 8, 2020
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Loss of ‘Jedi’ alters neuron activity
This is not the Jedi you're thinking of. This Jedi is a receptor that helps clear away dead neurons during development, and its loss changes the activity of dorsal root ganglia neurons, which could have implications for treating chronic pain. Read MoreMar 10, 2020