NIDDK
-
Dual-action enzyme protects esophagus
An antioxidant enzyme also functions as a tumor suppressor to limit cancer development in the esophagus. Read MoreMay 9, 2013
-
Food variety drives overeating in mouse model of obesity syndrome
Dietary variety – not high-fat or sugary foods – appears to stimulate overeating in a mouse model of an inherited obesity syndrome. Read MoreApr 25, 2013
-
‘Longevity’ gene aids kidney survival
A gene associated with cell survival and longevity may protect the kidney from acute injury. Read MoreApr 17, 2013
-
“Silent” B cells trigger autoimmunity
Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes. Read MoreApr 3, 2013
-
Plant compound stops colon cancer cells
Berberine, an herbal remedy for diarrhea and intestinal parasites, may be useful in colon cancer therapy. Read MoreMar 29, 2013
-
IRF6 on the tip of tongue development
The factor IRF6 plays important roles in the development of the tongue. Read MoreMar 18, 2013
-
Target for inflammatory bowel disease
The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments. Read MoreMar 1, 2013
-
Pancreas cells full of potential
Adult cells in the pancreas can return to a less mature state – and then become a different cell type, like the beta cells that secrete insulin. Read MoreFeb 18, 2013
-
Linking oxygen, iron and red blood cells
The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance. Read MoreFeb 6, 2013
-
Do-it-yourself repair in the kidney
The kidney can mediate its own repair through proliferation of resident immune system cells. Read MoreJan 31, 2013
-
HDL cholesterol impaired in kidney disease
HDL cholesterol is impaired in patients with chronic kidney disease – and may increase their cardiovascular disease risk. Read MoreJan 21, 2013
-
Study helps define pancreatic cancer’s cellular origins
Vanderbilt and University of California investigators have discovered the “cell of origin” for pancreatic ductal adenocarcinoma, a finding that could lead to early detection methods and new treatments. Read MoreJan 17, 2013
-
Cancer markers from archived tissue
Archived tissue samples are yielding new disease biomarkers. Read MoreDec 20, 2012
-
Bird’s eye view of gut development
A new map of the developing gut of quail offers valuable tool for studying intestinal diseases. Read MoreNov 19, 2012
-
Stomach bug alters tumor suppressor
The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer. Read MoreOct 23, 2012
-
Setting traps to probe gene function
A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function. Read MoreOct 18, 2012
-
How ‘Jedi’ disposes of dead neurons
The protein Syk is essential for clearing away neuron “corpses” in the developing peripheral nervous system. Read MoreSep 19, 2012
-
Enzyme counters stomach acid attack
Dysfunction or loss of an “antioxidant” enzyme may lead to higher risk for esophageal cancer in patients with gastric reflux disease. Read MoreSep 11, 2012
-
Ancestry impacts smoking risk for lungs
Smoking is more detrimental to lung function in individuals with high proportions of African ancestry. Read MoreAug 7, 2012
-
On the hunt for bladder cancer factors
A protein linked to aggressive bladder cancers could point to new strategies for treatment or prevention. Read MoreJul 26, 2012