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drug discovery Archives

Receptor discovery shines new light on appetite regulation

Nov. 20, 2014—A receptor in the brain that regulates appetite and body weight has now been found in L cells, key regulatory cells in the gut, providing the pharmaceutical industry with a novel drug target for both obesity and diabetes, a Vanderbilt University-led research team reported this week.

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Lung cancer study reveals new drug combination targets

Sep. 4, 2014—A Vanderbilt lung cancer patient’s exceptional response to different types of therapies spurred research that suggests lung cancer patients with specific gene alterations may benefit from combination therapy that targets two different cancer pathways.

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Enzyme holds the door for influenza

Aug. 20, 2014—Compounds developed at Vanderbilt University may offer a new way to block influenza infection.

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Growth factor blockade targets breast tumors

Aug. 14, 2014—Inhibition of BMP growth factor signaling reduces breast tumor burden and metastasis.

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Channel drug restores glucose balance

Apr. 16, 2014—A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis.

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Small molecule protects kidney filter

Mar. 19, 2014—A compound identified at Vanderbilt has therapeutic potential in protecting the kidney filter barrier.

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Fishing for new anti-cancer drugs

Sep. 18, 2013—Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.

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Institute of Chemical Biology to celebrate 10th anniversary

Feb. 28, 2013—Top chemists from around the country will be on hand March 12 to celebrate the 10th anniversary of the Vanderbilt Institute of Chemical Biology (VICB), a brave experiment that helped jumpstart the University’s robust drug discovery initiative.

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Structural snapshot hints at new influenza approach

Feb. 21, 2013—A careful look at how the body’s natural defenses disarm virulent strains of influenza hints at the possibility of a way to fight the flu.

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New tool for mining bacterial genome for novel drugs

Jan. 25, 2013—Vanderbilt biochemists have discovered that the process bacteria undergo when they become drug resistant can act as a powerful tool for drug discovery.

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Caving for Cures project gains museum limelight

Sep. 17, 2012—If you drop by the American Museum of Natural History the next time you visit New York, there is a good chance that you will see an exhibit highlighting Vanderbilt chemist Brian Bachmann’s "caving for drugs" research.

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Insights for neuroscience drug discovery

Jul. 17, 2012—When discovering drugs for brain disorders, it’s important to test the candidates in multiple ways to avoid advancing those with restricted physiological effects.

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