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drug discovery Archives

Rational design of novel antifungals

Oct. 7, 2015—Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections.

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Health and Medicine Reporter Research


Collaboration seeks to develop new therapies for bone, other diseases

Oct. 1, 2015—La Jolla Pharmaceutical Co. and Vanderbilt University have signed a research and license agreement covering Vanderbilt’s research program and intellectual property rights related to compounds that block bone morphogenetic protein (BMP) type-I receptors. The compounds have therapeutic potential in a broad range of diseases, including rare genetic disorders.

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Health and Medicine Healthcare Solutions Reporter Research


Drug signaling networks

Jul. 15, 2015—Vanderbilt investigators have developed a new algorithm to understand the networks of signaling molecules that control drug action.

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Health and Medicine Reporter Research


New strategy to combat HIV

Jun. 12, 2015—Inhibitors of the enzyme phospholipase D1 suppress the replication of HIV-1, Vanderbilt investigators have discovered.

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Health and Medicine Reporter Research


Grant spurs schizophrenia research

Feb. 12, 2015—Vanderbilt University is partnering with the William K. Warren Foundation of Tulsa, Oklahoma, on research aimed at improving the treatment of schizophrenia and other forms of serious mental illness.

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Health and Medicine Reporter Research Research Blog


Targeting HIV’s “cap”

Feb. 10, 2015—New findings underscore the attractiveness of the HIV capsid – the structure that encloses the viral genome – as a therapeutic target.

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Health and Medicine Reporter Research


Life’s extremists may be an untapped source of antibacterial drugs

Nov. 21, 2014—A family of single-celled organisms that thrive in environments too extreme for most other species to survive may be an untapped source of new antibacterial drugs.

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Life, Earth and Space Research


Receptor discovery shines new light on appetite regulation

Nov. 20, 2014—A receptor in the brain that regulates appetite and body weight has now been found in L cells, key regulatory cells in the gut, providing the pharmaceutical industry with a novel drug target for both obesity and diabetes, a Vanderbilt University-led research team reported this week.

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Health and Medicine Reporter Research


Lung cancer study reveals new drug combination targets

Sep. 4, 2014—A Vanderbilt lung cancer patient’s exceptional response to different types of therapies spurred research that suggests lung cancer patients with specific gene alterations may benefit from combination therapy that targets two different cancer pathways.

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Health and Medicine Reporter Research


Enzyme holds the door for influenza

Aug. 20, 2014—Compounds developed at Vanderbilt University may offer a new way to block influenza infection.

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Health and Medicine Reporter Research


Growth factor blockade targets breast tumors

Aug. 14, 2014—Inhibition of BMP growth factor signaling reduces breast tumor burden and metastasis.

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Health and Medicine Reporter Research


Channel drug restores glucose balance

Apr. 16, 2014—A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis.

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Health and Medicine Reporter Research


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