Drug Discovery

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis. Read More

A compound identified at Vanderbilt has therapeutic potential in protecting the kidney filter barrier. Read More

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug. Read More

Top chemists from around the country will be on hand March 12 to celebrate the 10th anniversary of the Vanderbilt Institute of Chemical Biology (VICB), a brave experiment that helped jumpstart the University’s robust drug discovery initiative. Read More

A careful look at how the body’s natural defenses disarm virulent strains of influenza hints at the possibility of a way to fight the flu. Read More

Vanderbilt biochemists have discovered that the process bacteria undergo when they become drug resistant can act as a powerful tool for drug discovery. Read More

If you drop by the American Museum of Natural History the next time you visit New York, there is a good chance that you will see an exhibit highlighting Vanderbilt chemist Brian Bachmann’s "caving for drugs" research. Read More

When discovering drugs for brain disorders, it’s important to test the candidates in multiple ways to avoid advancing those with restricted physiological effects. Read More

A new screening tool – using glowing fish embryos – could identify therapeutics for myocardial hypertrophy and heart failure. Read More

With the addition of a new 18,000-square-foot laboratory to be located within the Cool Springs Life Sciences Center, Vanderbilt University is expanding its research enterprise into Williamson County. Read More

Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool:… Read More

The progression of new drug candidates for schizophrenia with partner Janssen Pharmaceutica is the latest evidence that a new collaborative model for drug discovery pioneered at Vanderbilt may help identify and develop innovative candidate drugs for treatment of major brain disorders. Read More

Drug-like molecules described by Vanderbilt researchers could lead to Parkinson's treatments with fewer side effects. Read More

The discovery of new compounds that work in a fundamentally different way than those in existing schizophrenia medications may allow for more normal function of brain cells involved in schizophrenia. Read More

Researchers at Vanderbilt University Medical Center, in collaboration with Seaside Therapeutics in Cambridge, Mass., have achieved a milestone in the development of a potential new treatment for fragile X syndrome, the most common genetic cause of autism. Read More

Last week when the Nashville Scene’s annual Innovations Issue hit the newsstands, three of its ten “forward-thinking ideas that are pushing Nashville – and the world – into the future” came from Vanderbilt. The three campus projects that impressed the Scene editors were: Digging for Drugs:… Read More

Researchers have discovered how key proteins are “turned on” and transmit signals inside the cell. The discovery could lead to new, more effective drugs. Read More

A new laser technique can measure interactions between proteins tangled in a cell's membrane and a variety of other biological molecules: extremely difficult measurements that can aid the process of drug discovery. Read More

Vanderbilt University Medical Center has established a new Center for Neuroscience Drug Discovery to accelerate research that may lead to new treatments for Parkinson's disease, schizophrenia and other disorders of the brain. Read More

Researchers at Vanderbilt University are busy building the pharmacy of the future. On its shelves may be: • New medications for schizophrenia and Parkinson’s disease, and the first drug treatment for Fragile X syndrome; • A drug that can stop a particularly vicious form of breast cancer in its tracks;… Read More