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drug discovery Archives

New tool hooks heart failure drugs

Apr. 6, 2012—A new screening tool – using glowing fish embryos – could identify therapeutics for myocardial hypertrophy and heart failure.

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Vanderbilt expanding research enterprise into Williamson County

Mar. 9, 2012—With the addition of a new 18,000-square-foot laboratory to be located within the Cool Springs Life Sciences Center, Vanderbilt University is expanding its research enterprise into Williamson County.

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Fishing for heart attack repair tools

Jan. 5, 2012—Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool: zebrafish. The researchers visually screened...

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New schizophrenia drug candidates entering prep for first-in-human testing

Dec. 15, 2011—The progression of new drug candidates for schizophrenia with partner Janssen Pharmaceutica is the latest evidence that a new collaborative model for drug discovery pioneered at Vanderbilt may help identify and develop innovative candidate drugs for treatment of major brain disorders.

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Drug-like molecules aimed at improving treatment of Parkinson’s

Sep. 30, 2011—Drug-like molecules described by Vanderbilt researchers could lead to Parkinson's treatments with fewer side effects.

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New drug-like molecules could improve schizophrenia treatment

Sep. 22, 2011—The discovery of new compounds that work in a fundamentally different way than those in existing schizophrenia medications may allow for more normal function of brain cells involved in schizophrenia.

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Milestone in development of new treatment for ‘fragile X’

Sep. 15, 2011—Researchers at Vanderbilt University Medical Center, in collaboration with Seaside Therapeutics in Cambridge, Mass., have achieved a milestone in the development of a potential new treatment for fragile X syndrome, the most common genetic cause of autism.

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Nashville innovations

Aug. 23, 2011—Last week when the Nashville Scene’s annual Innovations Issue hit the newsstands, three of its ten “forward-thinking ideas that are pushing Nashville – and the world – into the future” came from Vanderbilt. The three campus projects that impressed the Scene editors were: Digging for Drugs: Cave Chemistry. This is an effort of Associate Professor...

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Discovery of how G proteins ‘turn on’ may lead to better drugs

Aug. 18, 2011—Researchers have discovered how key proteins are “turned on” and transmit signals inside the cell. The discovery could lead to new, more effective drugs.

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New laser technique opens doors for drug discovery

Mar. 14, 2011—A new laser technique can measure interactions between proteins tangled in a cell's membrane and a variety of other biological molecules: extremely difficult measurements that can aid the process of drug discovery.

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Neuroscience drug discovery center opens at Vanderbilt

Mar. 11, 2011—Vanderbilt University Medical Center has established a new Center for Neuroscience Drug Discovery to accelerate research that may lead to new treatments for Parkinson's disease, schizophrenia and other disorders of the brain.

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A new prescription for drug discovery

Feb. 3, 2011—Researchers at Vanderbilt University are busy building the pharmacy of the future. On its shelves may be: • New medications for schizophrenia and Parkinson’s disease, and the first drug treatment for Fragile X syndrome; • A drug that can stop a particularly vicious form of breast cancer in its tracks; • A replacement for acetaminophen...

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