• birth-control

    The importance of estrogen cycles

    Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer. Read More

    Aug 6, 2020

  • Vanderbilt University

    Post-transplant complication

    Vanderbilt researchers conducted the largest analysis to date of a heart complication in children following stem cell transplant. The findings may help guide screening practices to improve outcomes. Read More

    Jul 28, 2020

  • plant based milk soy

    Soy food, metabolism and the microbiome

    Consumption of soy foods may shape the microbiome and protect against hypertension only in individuals with soy-responsive microbiota, Vanderbilt researchers have discovered. Read More

    Jul 27, 2020

  • Helicobacter Pylori bacterium, medical illustration pathogenic microorganism in human stomach

    Stomach bug hit-and-run

    The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate. Read More

    Jul 23, 2020

  • 3d illustration of a ribonicleic acid chain from which the deoxyribonucleic acid or DNA is composed

    Cellular antiviral defenses

    A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses. Read More

    Jul 23, 2020

  • fat cells

    New tools to study bioactive lipids

    Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction. Read More

    Jul 14, 2020

  • arthritis

    “Nur” target may aid arthritis treatment

    Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells. Read More

    Jul 13, 2020

  • Urology

    Recurrent UTIs linked to hidden reservoir

    Bacterial invasion of vaginal cells sets up a protective niche and a reservoir for recurrent urinary tract infections, Vanderbilt researchers demonstrated. Read More

    Jul 9, 2020

  • Vanderbilt University

    Keeping beta cells “fit”

    Vanderbilt cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression. Read More

    Jul 9, 2020

  • schizophrenia

    A connection to schizophrenia

    The insula, a small region of the brain involved in diverse brain functions had widespread dysconnectivity in schizophrenia, Vanderbilt researchers found. Read More

    Jun 23, 2020

  • gene-mutation

    Single mutation causes seizure disorder

    A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities. Read More

    Jun 22, 2020

  • DNA helix with a piece cut off and set to the side

    Probing DNA damage repair

    After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

    Jun 18, 2020

  • 3d rendering of cells , virus or genetic molecule

    Studying cells in reduced dimensions

    Vanderbilt cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data. Read More

    Jun 18, 2020

  • Colony of bacteria in red culture material on petri dish held by hand wearing blue glove with other petri dish samples and test tubes in the background

    Staph’s activation of blood clotting

    Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests. Read More

    Jun 9, 2020

  • Human kidney cross section on scientific background. 3d illustration

    Protecting the injured kidney

    Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it. Read More

    Jun 4, 2020

  • syringe stuck like a dart into the bullseye of a black and gold target

    Potential new cancer target

    Vanderbilt researchers have discovered the involvement of a certain type of adenosine receptor in mediating signaling that supports tumor growth and metastasis. Read More

    Jun 4, 2020

  • Immune system concept: Illustration of a hand blocking the passage of a variety of bacteria and viruses

    Probing innate immunity

    Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA. Read More

    May 19, 2020

  • Close-up of dialysis tubing taped to arm of elderly African American man, resting on a red plaid blanket

    Implant one day may replace dialysis

    Vanderbilt researchers used pharmacological manipulations to increase salt and water transport by kidney cells grown in culture, a step necessary for realizing an implantable artificial kidney device. Read More

    May 18, 2020

  • Close-up photo of globe featuring Australia, Indonesia, New Zealand, Papua New Guinea, and portions of other surrounding island nations.

    Antibodies eye Pacific Island “fever”

    Vanderbilt Vaccine Center team isolates monoclonal antibodies against the mosquito-borne Ross River virus, which causes rash, fever and debilitating muscle and joint pain lasting three to six months. Read More

    May 14, 2020

  • illustration of anthrax spores

    The adaptable anthrax bacterium

    Vanderbilt researchers discover how anthrax bacterium defends itself against structural damage and resists the toxicity of the antimicrobial drug targocil. Read More

    May 14, 2020