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Aliquots Archives

Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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How Epo action is ‘enhanced’

Jul. 24, 2017—The hormone erythropoietin (Epo) controls red blood cell production and synthetic forms of Epo treat multiple disorders. New Vanderbilt research details how Epo works.

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Probing the genetics of autoimmunity

Jul. 21, 2017—Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets.

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Drivers of breast cancer metastasis

Jul. 20, 2017—Signaling through a complex of proteins called mTORC2 plays a role in breast cancer migration, invasion and metastasis, Vanderbilt researchers reported.

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Bile acids, microbiota and colon cancer

Jul. 5, 2017—Bile acids produced by a western diet alter the composition of the gut microbiota and promote intestinal carcinogenesis.

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NOTCH1 role in heart development

Jul. 3, 2017—The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.

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Cytokine linked to blindness

Jun. 30, 2017—A signaling molecule called interleukin-6 may be a therapeutic target to prevent vision loss or nerve degeneration in glaucoma, Vanderbilt researchers have discovered.

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Genetics of lung cancer survival

Jun. 29, 2017—Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans.

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STINGing combination for cancer

Jun. 19, 2017—A novel immunotherapy combination induced remarkable regression of tumors in a mouse model of head and neck cancer.

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PET imaging to predict tumor response

Jun. 14, 2017—A PET probe that detects the amino acid glutamine predicts whether tumors respond to certain targeted therapies in preclinical animal models.

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Repriming replication roadblocks

Jun. 12, 2017—New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.

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Flip side of gut protection

Jun. 9, 2017—Vanderbilt investigators report that dysregulation of certain immune cells in the intestines may lead to inflammation and disease.

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