NIH
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Three Vanderbilt scientists awarded NIH grants for high-risk, high-reward research
Vanderbilt scientists Katherine Aboud, PhD’19, Breann Brown and Will Wan, PhD’14, have received 2021 National Institutes of Health Director’s Awards for their unconventional, bold approaches to research that advances knowledge and enhances health. Read MoreOct 5, 2021
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The role of polarity in early cancer
Mutations in the protein epiregulin, an EGF receptor ligand, affect larger epithelial cell reorganization and may contribute to early cancer development, Vanderbilt researchers discovered. Read MoreSep 21, 2021
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Brain circuits in schizophrenia
Vanderbilt psychiatrists are probing brain circuit hyperactivity implicated in schizophrenia, with the idea that normalizing the hyperactivity may improve cognitive processes. Read MoreSep 20, 2021
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Structural variants in breast cancer risk genes
Vanderbilt epidemiologists conducted in-depth whole genome sequencing of breast cancer risk genes in Black women, who die at higher rates and have more aggressive disease, to discover mutations that may improve testing and treatment selection. Read MoreSep 16, 2021
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‘Pre-conditioning’ restores immune tolerance
A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered. Read MoreSep 16, 2021
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Team awarded $2.3 million NIH grant to evaluate new, more accurate ultrasound methods
New acquisition and reconstruction solutions for ultrasound imaging developed by a Vanderbilt team aim to fundamentally improve the ability to obtain high quality, clinically relevant images, especially in cases of heart disease. With a new, $2.3 million National Institutes of Health grant, the researchers will evaluate their advances on a specific subset of cardiac imaging... Read MoreSep 9, 2021
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$1.9 million NIH project to investigate effects of shear stress on cancer cells
A biomedical engineering professor has received a $1.9 million NIH grant to investigate the effects of mechanical stimuli such as shear stress on the behavior of cancer cells in blood flow. J. Lawrence Wilson Professor Mike King and his research group will develop the devices for the study as well as new cell lines to... Read MoreSep 9, 2021
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$1.9 million NIH project to investigate effects of shear stress on cancer cells
A biomedical engineering professor has received a $1.9 million NIH grant to investigate the effects of mechanical stimuli such as shear stress on the behavior of cancer cells in blood flow. J. Lawrence Wilson Professor Mike King and his research group will develop the devices for the study as well as new cell lines to... Read MoreSep 9, 2021
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Using billing codes to count cancers
The billing codes in electronic health records are useful for counting skin cancers over time — an important metric for cancer risk assessment and prevention. Read MoreSep 2, 2021
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Sudden death from deep in the brain?
Vanderbilt neurologists found altered excitability in deep brain structures that they note may drive respiratory dysfunction and sudden death in a rare form of epilepsy. Read MoreAug 9, 2021
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Motor protein linked to intestinal cell differentiation
The motor protein MYO5B, a cause of the congenital intestinal disorder microvillus inclusion disease, does more than move cellular cargo, Vanderbilt researchers have discovered. Read MoreAug 5, 2021
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Gene expression in diabetic nephropathy
Vanderbilt researchers are looking to mRNA populations in podocytes — kidney cells that help filter blood — to help identify potential targets for treating diabetic kidney disease. Read MoreAug 5, 2021
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Prediction models for breast cancer
Vanderbilt researchers developed new prognostic models for breast cancer outcomes and found that adding postdiagnostic weight change as a factor improves the prediction. Read MoreJul 27, 2021
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Mood and cognition after chemotherapy
Validation of cognitive complaints appears to improve mood in patients with persistent chemotherapy-cognitive impairment, Vanderbilt researchers report. Read MoreJul 26, 2021
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Researchers discover that protein switches functions to regulate DNA replication
Vanderbilt biochemists have discovered that the protein RADX has different biological effects at sites of DNA synthesis, depending on the cellular conditions — even though it works the same way in both stressed and unstressed cells. Read MoreJul 22, 2021
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Influenza network sizes up COVID
Hospital data from a CDC network that monitors influenza revealed that adults hospitalized for COVID-19 in the early months of the pandemic were 20x more likely to die compared to hospitalized influenza patients. Read MoreJul 22, 2021
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School of Nursing awarded NIH grant to integrate genomics education into clinical and research-based nursing fields
Associate Professor of Nursing Laurie Connors has received a grant from the National Institutes of Health National Human Genome Research Institute to train doctoral nurses in the translation and integration of genomics into academics, research and clinical practice. Read MoreJul 13, 2021
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Establishing HIV care in Tennessee
Vanderbilt researchers find that heterosexually active Black males are the least likely to establish HIV care within one month of diagnosis and suggest that targeted interventions focus on this population. Read MoreJul 13, 2021
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Probing statin-associated diseases with genetics
Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases. Read MoreJul 12, 2021
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Delirium and mortality reexamined
A multicenter study of ICU patients found that in the hospital, delirium was associated with a nearly three-fold increase in risk of death the following day, but after discharge there was no association between delirium and mortality. Read MoreJul 8, 2021