NIH
Mitochondrial stress and hypertension
Jan. 12, 2021—Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential.
Microbial RNA and rheumatoid arthritis
Jan. 11, 2021—Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases.
Vitamin D activation and cancer risk
Jan. 7, 2021—Vitamin D protection against colon cancer varies according to parathyroid hormone response, particularly among women.
Building a cohort, the easy way
Jan. 7, 2021—An automated system using keyword searches can help identify candidates for clinical trials on adverse drug reactions.
Polymer protection for heart muscle
Dec. 14, 2020—Vanderbilt researchers demonstrate that the polymer P188 has promise as a therapy to prevent reperfusion injury — the cellular damage that occurs when blood flow returns after an ischemic event like a heart attack.
Model students: improving clinical decision-making
Dec. 10, 2020—Vanderbilt investigators have devised a system to alert health IT teams to deteriorating performance in clinical prediction models.
Exploiting viral vulnerabilities
Dec. 10, 2020—The isolation of human monoclonal antibodies against dangerous viruses including EEEV, Hendra and Nipah could offer new ways to treat and prevent these infections.
Study details early events of inflammatory response
Dec. 10, 2020—Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis.
Vanderbilt awarded NIH grant to continue mentoring and career training among biomedical research graduate students from underrepresented groups
Dec. 1, 2020—The Vanderbilt School of Medicine Basic Sciences has won continued funding from the National Institutes of Health for its Initiative for Maximizing Student Diversity program supporting the success of biomedical graduate students from underrepresented backgrounds.
A cohort for type 2 diabetes studies
Nov. 17, 2020—A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs.
Imaging “biomarker” for Alzheimer’s disease progression
Nov. 16, 2020—Changes in connectivity in the brain’s white matter may be a novel neuroimaging biomarker for assessing Alzheimer’s disease progression.
New therapeutic target for lung cancer
Nov. 12, 2020—Vanderbilt researchers have identified a new molecular partner — and potential therapeutic target — in a signaling axis that drives lung cancer.