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Vanderbilt-led team discovers new genetic disease and defines underlying mechanism

Jan. 13, 2020—An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms.

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Zinc uptake by a deadly pathogen

Jan. 13, 2020—The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses.

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Study links Medicaid expansion and recipients’ health status

Jan. 10, 2020—In Southern states that expanded their Medicaid programs under the Affordable Care Act, adults experienced lower rates of decline in both physical and mental health, according to a new Vanderbilt analysis.

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Bone matrix changes during aging

Jan. 10, 2020—Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis.

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Structural views of a C. diff toxin

Jan. 10, 2020—D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

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Cell fate signaling

Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

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Protein dynamics in the beating heart

Dec. 16, 2019—To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction.

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A new anti-seizure target?

Dec. 12, 2019—Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.

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Gregor Mendel would be proud

Dec. 12, 2019—A computational method that uses hospital billing codes and electronic health records can identify genetic disease cases before clinical teams do.

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Genetic screen in worms reveals critical step in insulin synthesis

Dec. 4, 2019—The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes.

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Getting the goods on obesity

Nov. 19, 2019—Obesity and two post-operative complications linked with it have associated genetic variants in common, suggesting that obesity may be the culprit.

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Understanding cell division

Nov. 18, 2019—Vanderbilt researchers have uncovered another piece in the puzzle of how cells divide — a process that goes awry in cancer cells.

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