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Steroid binding to metabolic enzyme

Jun. 12, 2019—Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

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Cell-cell signals in developing heart

Jun. 10, 2019—Scott Baldwin and colleagues have discovered early signaling events during heart development, findings that could guide cell replacement therapies for heart disease.

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Mouth health and colorectal cancer

Jun. 6, 2019—Microbial species in the mouth could be playing a role in colorectal cancer development, according to new research from epidemiologists at VUMC.

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Study details regulation of a multi-drug transporter

May. 30, 2019—Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action. The new findings could guide the development of more efficient inhibitors to prevent cancer cell resistance to chemotherapy.

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Frog fungus fights back

May. 15, 2019—Louise Rollins-Smith and colleagues have discovered a new way that a deadly fungus evades frogs' immune systems.

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Dynamic basement membranes

May. 9, 2019—Basement membranes are important structural and functional components of tissues. New research provides insight into how they repair themselves.

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Blueprint for rebuilding the heart

May. 9, 2019—New findings may speed progress toward programming cells to rebuild damaged hearts more quickly.

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Researchers find high-risk genes for schizophrenia

Apr. 18, 2019—Using a unique computational framework they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute has identified 104 high-risk genes for schizophrenia.

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Indicators of despair rising among Gen X-ers entering middle age

Apr. 15, 2019—In 2016, a surprising decline in life expectancy was ascribed to "deaths of despair" among working-class middle-aged white men displaced by a changing economy. However, new research shows indicators of despair are rising among Americans approaching middle age regardless of race, education and gender.

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How bugs overcome host defenses

Apr. 12, 2019—Eric Skaar and colleagues have figured out how a common bug responsible for ventilator-associated pneumonia responds when starved of zinc, a metal it needs to survive, which may lead to new therapeutic targets for the dangerous infection.

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Discovery aids search for cancer biomarkers

Apr. 12, 2019—A report by researchers at Vanderbilt University Medical Center has shattered conventional wisdom about how cells, including cancer cells, shed DNA into the bloodstream.

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The arrestin-GPCR connection

Apr. 12, 2019—Vsevolod Gurevich and colleagues have discovered new insights into arrestin proteins, which turn off a cell's environmental message "inbox."

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