NCATS

New findings suggest that misfolded proteins accumulate in the heart atria, particularly in patients with hypertension, and may contribute to atrial heart disease. Read More

A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression. Read More

Vanderbilt researchers will play a key role in the second phase of the federal "tissue chip for drug screening" program. Read More

An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial. Read More

A person’s mitochondrial gene “signature” could predict risk for diabetic retinopathy and guide early intervention strategies. Read More

Vanderbilt investigators identify a new therapeutic target for the inflammatory lung disease sarcoidosis. Read More

A combination treatment delivered to the site of fractures may improve bone healing in patients with the genetic disease neurofibromatosis type-1. Read More

Vanderbilt researchers have identified a new target for blocking breast cancer metastasis. Read More

Early weight regain after gastric bypass surgery does not reverse metabolic improvements, and the "hunger hormone" ghrelin might indicate who is susceptible to weight regain. Read More

An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered. Read More

The protein MTBP is overexpressed in an aggressive type of breast cancer, and it regulates another protein implicated in many cancer types, suggesting that it may be a good target for new therapeutics. Read More

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine. Read More

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication. Read More

Electronic medical records linked to DNA biobanks are a valid resource for defining and understanding the genetic factors that contribute to drug response. Read More

Vanderbilt investigators have used two types of neuroimaging to establish a “map” of connections for a brain region important in anxiety and addiction. Read More

Influenza and parainfluenza infections – but not other respiratory viruses – increase the risk of acquiring pneumococcal bacteria, the most common cause of severe pneumonia. Read More

Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge. Read More

by Denise Anthony (iStock) A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast?… Read More

Vanderbilt researchers have discovered that variation in the gene encoding the potassium channel GIRK1 plays a role in modulating human pain perception. Read More

The breast cancer drug tamoxifen improves cognitive performance in post-menopausal women. Read More