Hassane Mchaourab
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Research Snapshot: Spectroscopy and AI method provide unique window into protein structure and mechanism of action
The lab of Hassane Mchaourab, director of the Center for Applied Artificial Intelligence in Protein Dynamics and professor of molecular physiology and biophysics, has developed a methodological blueprint that couples experimental double electron–electron resonance spectroscopy with an AI approach to help describe the conformational landscapes of a diverse spectrum of cell membrane transporters. Read MoreDec 4, 2024
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Computing Catalyst Working Group to shape expanded computing resources and capabilities to advance university-wide research
The Computing Catalyst Working Group will identify computing resources needed to catalyze a new wave of discovery and innovation powered by AI and computing at Vanderbilt. Read MoreMay 2, 2024
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Vanderbilt launches Center for Applied Artificial Intelligence in Protein Dynamics
Led by Vanderbilt University School of Medicine Basic Sciences professor Hassane Mchaourab, the Center for Applied Artificial Intelligence in Protein Dynamics will focus on the application of machine learning techniques to understand how proteins work. Read MoreApr 12, 2023
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Watch: Lab-to-Table Conversation: ‘Biomedical Research Ethics and the Scientific Method’
Join Hassane Mchaourab, the Louise B. McGavock Professor and professor of molecular physiology and biophysics, as he explores biomedical ethics with leading experts in law, biomedical research and basic sciences on Thursday, Sept. 29, from 11 a.m. to noon. Read MoreSep 20, 2022
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Study explores how bacteria become drug resistant
Vanderbilt researchers have revealed more of the inner-workings of a two-stage “molecular motor” in the cell membrane that enables bacteria to become resistant to drugs. Read MoreJan 6, 2022
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Study details regulation of a multi-drug transporter
Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action. The new findings could guide the development of more efficient inhibitors to prevent cancer cell resistance to chemotherapy. Read MoreMay 30, 2019
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Fueling the MATE transporter
In new research, Hassane Mchaourab and colleagues have uncovered new insights into drug resistance that could lead to the development of new anti-cancer and antibacterial drugs. Read MoreJul 20, 2018
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Faculty meeting recognizes excellence in education, research and clinical service
During Wednesday’s Spring Faculty Meeting, Jeff Balser, M.D., Ph.D., dean of Vanderbilt University School of Medicine and President and CEO of Vanderbilt University Medical Center, highlighted the medical school’s rising stature among the country’s top-tier institutions. Read MoreMay 24, 2018
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A cataract-heart connection
Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease. Read MoreJan 25, 2018
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Study catches ‘notorious’ drug pump in action
Researchers at Vanderbilt University Medical Center (VUMC) have mapped the conformational changes that occur in a protein “notorious” for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system. Read MoreMar 16, 2017
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Membrane fats impact drug transporter
New studies of a membrane transporter could explain antibiotic resistance – and lead to novel ways to combat it. Read MoreJul 14, 2016
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Dynamics of a drug resistance transporter
Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance. Read MoreFeb 5, 2016
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Grad students welcome at Oct. 14 forum discussing graduate education at VU
The purpose of the event is to capture feedback on the proposals of the Graduate Education Study Group’s executive summary from current graduate students. Read MoreOct 8, 2015
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Next graduate education forum is Oct. 5
The third in a series of forums discussing graduate education at Vanderbilt is scheduled for Monday, Oct. 5, from 4 to 5 p.m. in the Student Life Center Board of Trust Room. Read MoreSep 30, 2015
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Next graduate education forum set for Sept. 24
The second in a series of forums discussing graduate education at Vanderbilt is scheduled for Thursday, Sept. 24. Read MoreSep 21, 2015
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In a zebrafish’s eye
Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts. Read MoreJul 29, 2015
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New view of transporter dynamics
New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants. Read MoreOct 23, 2014
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New Graduate Education Study Group to begin work Oct. 1
Provost and Vice Chancellor for Academic Affairs Susan Wente has appointed a new Graduate Education Study Group and charged it with laying the course for the future of graduate education at Vanderbilt. Read MoreSep 22, 2014
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Team takes 4-D look at brain receptor’s role
Reporting last week in the journal Cell, researchers from Oregon Health and Science University, Harvard Medical School and Vanderbilt University describe the first “four-dimensional” picture of a brain receptor that plays a key role in learning and memory. Read MoreAug 14, 2014
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How ABC transporters move molecules
New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis. Read MoreJun 13, 2014