Hassane Mchaourab

The lab of Hassane Mchaourab, director of the Center for Applied Artificial Intelligence in Protein Dynamics and professor of molecular physiology and biophysics, has developed a methodological blueprint that couples experimental double electron–electron resonance spectroscopy with an AI approach to help describe the conformational landscapes of a diverse spectrum of cell membrane transporters. Read More

The Computing Catalyst Working Group will identify computing resources needed to catalyze a new wave of discovery and innovation powered by AI and computing at Vanderbilt.  Read More

Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action. The new findings could guide the development of more efficient inhibitors to prevent cancer cell resistance to chemotherapy. Read More

In new research, Hassane Mchaourab and colleagues have uncovered new insights into drug resistance that could lead to the development of new anti-cancer and antibacterial drugs. Read More

During Wednesday’s Spring Faculty Meeting, Jeff Balser, M.D., Ph.D., dean of Vanderbilt University School of Medicine and President and CEO of Vanderbilt University Medical Center, highlighted the medical school’s rising stature among the country’s top-tier institutions. Read More

Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease. Read More

Researchers at Vanderbilt University Medical Center (VUMC) have mapped the conformational changes that occur in a protein “notorious” for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system. Read More

New studies of a membrane transporter could explain antibiotic resistance – and lead to novel ways to combat it. Read More

Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance. Read More

Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts. Read More

New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants. Read More

Reporting last week in the journal Cell, researchers from Oregon Health and Science University, Harvard Medical School and Vanderbilt University describe the first “four-dimensional” picture of a brain receptor that plays a key role in learning and memory. Read More

New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis. Read More

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders. Read More

Vanderbilt University researchers and their Belgian colleagues have discovered the mechanism behind a multidrug transporter. Their findings, posted this week by Nature Chemical Biology, could lead to new treatments for multidrug resistant bacterial infections. Read More

Hassane Mchaourab, Ph.D., professor of Molecular Physiology & Biophysics, Physics and Chemistry, has been named the new director of the Ph.D.-granting Chemical and Physical Biology (CPB) program at Vanderbilt University. Read More

New molecular views of an enzyme may inform therapies for neurological, psychiatric or cardiac diseases. Read More