Department Of Veterans Affairs

Racial disparities in hypertension risk are due in part to genetic differences between ancestries, Vanderbilt investigators find in a study of participants in the Million Veteran Program. Read More

Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function. Read More

Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years. Read More

Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine. Read More

Disrupting the action of glucagon — a pancreatic hormone that works to raise blood glucose — restores functional insulin-producing cells in mouse models of type 1 diabetes and may be a promising treatment strategy. Read More

Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases. Read More

Vanderbilt researchers demonstrate that the polymer P188 has promise as a therapy to prevent reperfusion injury — the cellular damage that occurs when blood flow returns after an ischemic event like a heart attack. Read More

A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs. Read More

Vanderbilt researchers have identified a new molecular partner — and potential therapeutic target — in a signaling axis that drives lung cancer. Read More

Vanderbilt researchers have identified a signaling pathway that promotes kidney fibrosis in patients with diabetes — and that could be targeted with an existing approved medication. Read More

Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read More

Vanderbilt scientists have discovered a new target for normalizing tumor blood vessels to improve cancer immunotherapies. Read More

While 60 percent of people with metastatic melanoma, an aggressive type of skin cancer, have multiple treatment options available to them, roughly 40 percent either do not respond to treatment, or relapse. Read More

The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate. Read More

Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells. Read More

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it. Read More

A new partnership between the Divinity School and Mental Health and Chaplaincy, a national program of the Veterans Health Administration, will relaunch a doctor of ministry program at Vanderbilt. Read More

Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth. Read More

Timothy Cover and colleagues report new insights into the sources of energy used by a bacterial “machine” linked to the pathogenesis of stomach cancer. Read More

Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis. Read More