Department Of Veterans Affairs

A metabolic change in adult stem cells makes them less “fit” for regenerative heart therapies, suggesting that strategies to prevent this response may boost the therapeutic usefulness of the cells. Read More

A novel mechanism could point to new therapies for a group of inherited diseases that share pathological features. Read More

Pediatric patients have a significantly higher incidence of transfusion reactions compared to adults, according to a study by Vanderbilt University researchers. Read More

New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas. Read More

TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling. Read More

Vanderbilt researchers have identified a new protein involved in heart cell growth, which could improve understanding of pathologic cardiac hypertrophy. Read More

A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression. Read More

The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells. Read More

Soldiers deployed to tropical and sunny climates are coming home with increased risk factors for a threat far from the battlefield: skin cancer. Read More

The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets. Read More

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication. Read More

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation. Read More

Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge. Read More

A new mouse model reveals gene clusters important in a treatment-resistant form of leukemia. Read More

Targeting the production of molecules that promote tumor blood vessel development offers a new path for treating lung cancer. Read More

It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity. Read More

Vanderbilt researchers describe a new technique for identifying factors that stimulate the proliferation of pancreatic beta cells – factors that might offer therapeutic options for diabetes. Read More

A protein kinase linked to inflammation and tumor development may be a good target for gastric cancer therapies. Read More

Inhibitors of a signaling pathway that is critical to synovial sarcoma tumorigenesis may be useful treatments for this aggressive cancer. Read More

In the latest VUCast: ICU patients are leaving hospitals with a dementia-like disease; What’s the fate of the Republican Party?; Hear from Pulitzer Prize-winning author and Distinguished Visiting Professor Jon Meacham; and It's time to celebrate -- the Rate My Professor 2013 rankings are in. All this and more in Vanderbilt’s online newscast. Watch now. Read More