Department Of Veterans Affairs

  • Helicobacter Pylori bacterium, medical illustration pathogenic microorganism in human stomach

    H. pylori, lipid loss and stomach cancer

    H. pylori infection — a strong risk factor for stomach cancer — changes the composition of stomach lipids, which could offer new biomarkers for detecting premalignant changes, Vanderbilt researchers discovered. Read More

    Jan. 17, 2022

  • Human kidney cross section on scientific background. 3d illustration

    The role of integrins in kidney “integrity”

    Receptors called integrins play a critical role in maintaining the structure of the kidney, Vanderbilt researchers have discovered. Read More

    Jan. 13, 2022

  • x-ray of a pancreas highlighted in red

    Uncovering how injury to the pancreas impacts cancer formation

    Research from scientists at the School of Medicine Basic Sciences and the Salk Institute for Biological Studies shows that cells in the pancreas form new cell types to mitigate injury but are then susceptible to cancerous mutations. Read More

    Oct. 29, 2021

  • Vanderbilt University

    Vitamin D impact on disease biomarkers

    In a randomized controlled trial, vitamin D supplementation did not improve biomarkers for cardiovascular and metabolic disease. Read More

    Aug. 10, 2021

  • Human kidney cross section on scientific background. 3d illustration

    Gene expression in diabetic nephropathy

    Vanderbilt researchers are looking to mRNA populations in podocytes — kidney cells that help filter blood — to help identify potential targets for treating diabetic kidney disease. Read More

    Aug. 5, 2021

  • Vanderbilt University

    Beta cell regeneration

    Vanderbilt researchers dissected the complex microenvironment of the pancreatic islet to discover the signals that drive beta cell regeneration — as a possible treatment for diabetes. Read More

    May. 20, 2021

  • doctor checking patient's blood pressure

    Genetic ancestry and hypertension risk

    Racial disparities in hypertension risk are due in part to genetic differences between ancestries, Vanderbilt investigators find in a study of participants in the Million Veteran Program. Read More

    Apr. 29, 2021

  • Human kidney cross section on scientific background. 3d illustration

    New insights into kidney development

    Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function. Read More

    Apr. 15, 2021

  • Vanderbilt University

    Study revises understanding of cancer metabolism

    Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years. Read More

    Apr. 7, 2021

  • white pills spilling out of a prescription bottle

    Codeine metabolizer status in clinical practice

    Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine. Read More

    Apr. 5, 2021

  • Vanderbilt University

    Targeting glucagon action in diabetes

    Disrupting the action of glucagon — a pancreatic hormone that works to raise blood glucose — restores functional insulin-producing cells in mouse models of type 1 diabetes and may be a promising treatment strategy. Read More

    Mar. 4, 2021

  • arthritis

    Microbial RNA and rheumatoid arthritis

    Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases. Read More

    Jan. 11, 2021

  • Digital illustration of heart in an x-ray of a human chest

    Polymer protection for heart muscle

    Vanderbilt researchers demonstrate that the polymer P188 has promise as a therapy to prevent reperfusion injury — the cellular damage that occurs when blood flow returns after an ischemic event like a heart attack. Read More

    Dec. 14, 2020

  • diabetes

    A cohort for type 2 diabetes studies

    A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs. Read More

    Nov. 17, 2020

  • x-ray of lungs with a suspicious spot highlighted in red

    New therapeutic target for lung cancer

    Vanderbilt researchers have identified a new molecular partner — and potential therapeutic target — in a signaling axis that drives lung cancer. Read More

    Nov. 12, 2020

  • Vanderbilt University

    Clue to diabetic kidney disease

    Vanderbilt researchers have identified a signaling pathway that promotes kidney fibrosis in patients with diabetes — and that could be targeted with an existing approved medication. Read More

    Oct. 5, 2020

  • Vanderbilt University

    Rational vaccine design

    Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read More

    Sep. 22, 2020

  • close up of blood vessels

    A “torque” for tumor blood vessels

    Vanderbilt scientists have discovered a new target for normalizing tumor blood vessels to improve cancer immunotherapies. Read More

    Aug. 20, 2020

  • metastatic melanoma

    A potential new targeted therapy for metastatic melanoma

    While 60 percent of people with metastatic melanoma, an aggressive type of skin cancer, have multiple treatment options available to them, roughly 40 percent either do not respond to treatment, or relapse. Read More

    Aug. 19, 2020

  • Helicobacter Pylori bacterium, medical illustration pathogenic microorganism in human stomach

    Stomach bug hit-and-run

    The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate. Read More

    Jul. 23, 2020