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Department of Veterans Affairs Archives

Kids more likely to react to blood transfusions

May. 4, 2015—Pediatric patients have a significantly higher incidence of transfusion reactions compared to adults, according to a study by Vanderbilt University researchers.

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Boosting beta cells in diabetes

Apr. 20, 2015—New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas.

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Surprising finding in the kidney

Apr. 16, 2015—TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling.

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New player in heart cell growth

Apr. 6, 2015—Vanderbilt researchers have identified a new protein involved in heart cell growth, which could improve understanding of pathologic cardiac hypertrophy.

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Target for atherosclerosis therapies

Dec. 17, 2014—A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression.

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Immune cell activity and melanoma

Nov. 6, 2014—The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells.

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Skin cancer risks higher for soldiers serving abroad

Sep. 11, 2014—Soldiers deployed to tropical and sunny climates are coming home with increased risk factors for a threat far from the battlefield: skin cancer.

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Factor impacts bone toughness

Jun. 16, 2014—The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets.

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Potential mechanism for myeloma drug’s variable toxicity

Apr. 30, 2014—A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

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Increased cell permeability may protect from colitis

Apr. 25, 2014—Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.

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Delirium increases long-term disability

Mar. 17, 2014—Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge.

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Probing the pathogenesis of leukemia

Feb. 27, 2014—A new mouse model reveals gene clusters important in a treatment-resistant form of leukemia.

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