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Health and Medicine

Low health literacy associated with early death for cardiovascular patients

Nov. 8, 2018—Patients hospitalized with a cardiovascular event are more likely to die within one year if they have low health literacy, according to new research by Lindsay Mayberry and Sunil Kripalani.

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Evading cell death

Nov. 8, 2018—Susan Wente and Laura Glass have developed an experimental cell culture model system to investigate the link between stress granules and cell resistance to toxic stress, which could lead to new avenues for treating cancer treatment resistance.

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Vitamin C protects brain from seizures

Nov. 8, 2018—Fiona Harrison and colleagues have found evidence that Vitamin C can help protect brains against seizures and cognitive decline in Alzheimer’s disease.

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Novel methods to treat glaucoma

Nov. 8, 2018—Rebecca Sappington and colleagues have found that increasing cGMP — part of a signaling pathway that was previously found to regulate intraocular pressure — protects retinal ganglion cells affected by glaucoma.

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Obesity negates beneficial drug effects

Nov. 8, 2018—Lin Zhu and Rob Stafford have found that obesity interferes with cholesterol-improving CTEP inhibitors.

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Team’s findings show glutamine metabolism affects T cell signaling

Nov. 1, 2018—Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases.

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Team seeks to identify immune response to influenza

Nov. 1, 2018—Vanderbilt researchers led by Buddy Creech are searching for the key to lasting protection against influenza by examining naturally protecting cells found in bone marrow.

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Mary Kay Foundation grant to bolster immunotherapy research

Oct. 26, 2018—The grant will allow Charles Caskey to lead research into using ultrasound as an image-guided therapy for drug delivery.

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Grant to help explore critical issues in Down syndrome

Oct. 26, 2018—The grant will allow Kennedy Center researchers to analyze data from VUMC's Synthetic Derivative and BioVU databanks to study biomarkers associated with Down Syndrome.

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Probing the pathology of impaired cognition

Oct. 26, 2018—A new link between a support protein within the brain's white matter and known Alzheimer's biomarkers discovered by Angela Jefferson and colleagues bring researchers a step toward earlier and more precise detection of neuropathology underlying cognitive impairment that may lead to new targeted therapies

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Grant enhances study of new chemotherapy targets

Oct. 19, 2018—Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

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Targeting diabetic kidney disease

Oct. 16, 2018—Raymond Harris, Ming-Zhi Zhang and colleagues suggest pathways activated by the epidermal growth factor receptor may be promising targets for treating diabetic kidney disease.

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