Research

The Outcomes Related to COVID-19 Treated with Hydroxychloroquine among In-patients with Symptomatic Disease (ORCHID) trial stopped enrolling new patients based on the fourth scheduled interim analysis showing no evidence of benefit or harm.  Read More

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

Vanderbilt cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data. Read More

On May 27, the All of Us Research Program launched the beta version of its cloud-based research platform, the Researcher Workbench. Read More

The goal of the project—Risk-Aware Market Clearing—is a blueprint for an end-to-end, data-driven approach that balances cost and minimizes system-level risk. Market clearing is the process that keeps the supply level to the demand with no leftover of either. Read More

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions. Read More

Vanderbilt University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics. Read More

After evaluating the ability of more than 1,500 monoclonal antibodies to bind and neutralize the COVID-19 virus, SARS-CoV-2, in the laboratory, AstraZeneca signed an exclusive license to six candidate antibodies in Vanderbilt’s portfolio. Read More

Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests. Read More

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it. Read More

Vanderbilt researchers have discovered the involvement of a certain type of adenosine receptor in mediating signaling that supports tumor growth and metastasis. Read More

The investigational antiviral drug remdesivir can shorten the time to recovery in adults hospitalized with COVID-19, according to preliminary results of a clinical trial published last month in The New England Journal of Medicine. Read More

People with cancer sickened by COVID-19 have a crude death rate of 13%, according to the largest series of data released thus far from a multinational perspective. The data on more than 900 patients also revealed cancer-specific factors associated with increased mortality. Read More

Jonathan Irish joins an international collaboration by deploying artificial intelligence to optimize COVID-19 treatment and vaccine development. Read More

A new paper proposes an ethical way to test drug safety during pregnancy by using electronic health data to conduct "virtual" drug trials. Read More

Lung disease experts at Vanderbilt University Medical Center and their colleagues have determined a key factor as to why COVID-19 appears to infect and sicken adults and older people preferentially while seeming to spare younger children. Read More

In recent years a cadre of energetic, productive faculty members have joined Peabody's special education department, building on the legacy of high-caliber research and teaching that began in the 1950s with Lloyd Dunn and developmental psychologists Nicholas Hobbs and Susan Gray. Read More

Nancy Carrasco has found that the environmental pollutant perchlorate, found in drinking water in 49 states, is more dangerous than we knew. Read More

Kate Clouse is working with researchers at the University of Cape Town to develop a phone app that will help new mothers with HIV in South Africa stay connected to the healthcare system during the perinatal period. Read More

As Nashville cautiously begins to emerge from its two-month-long COVID-19 Safer at Home response, so too are the labs and facilities at Vanderbilt University Medical Center. Read More