Health And Medicine
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VUMC Research Enterprise begins ramping up
As Nashville cautiously begins to emerge from its two-month-long COVID-19 Safer at Home response, so too are the labs and facilities at Vanderbilt University Medical Center. Read MoreMay 19, 2020
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Probing innate immunity
Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA. Read MoreMay 19, 2020
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Implant one day may replace dialysis
Vanderbilt researchers used pharmacological manipulations to increase salt and water transport by kidney cells grown in culture, a step necessary for realizing an implantable artificial kidney device. Read MoreMay 18, 2020
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Study to determine rate of novel coronavirus infection in U.S. children
Researchers at Vanderbilt University Medical Center are leading a nationwide study to determine the rate of novel coronavirus infection in U.S. children and their families. Read MoreMay 14, 2020
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Study finds newborn opioid withdrawal rates show evidence of stabilizing
Rates of neonatal abstinence syndrome have plateaued after 20 years of increasing frequency across the country, according to a new study published in Health Affairs. Read MoreMay 14, 2020
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Antibodies eye Pacific Island “fever”
Vanderbilt Vaccine Center team isolates monoclonal antibodies against the mosquito-borne Ross River virus, which causes rash, fever and debilitating muscle and joint pain lasting three to six months. Read MoreMay 14, 2020
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The adaptable anthrax bacterium
Vanderbilt researchers discover how anthrax bacterium defends itself against structural damage and resists the toxicity of the antimicrobial drug targocil. Read MoreMay 14, 2020
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Yin receives early investigator MERIT Award from NCI
Zhijun Yin, PhD, assistant professor of Biomedical Informatics at Vanderbilt University Medical Center, has received the National Cancer Institute’s Method to Extend Research in Time Award (or MERIT Award) for Early Stage Investigators. Read MoreMay 14, 2020
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New method captures early viral-host protein interactions
Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins. Read MoreMay 7, 2020
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Study finds AI can categorize cancer risk of lung nodules
Computed tomography scans for people at risk for lung cancer lead to earlier diagnoses and improve survival rates, but they can also lead to overtreatment when suspicious nodules turn out to be benign. Read MoreMay 7, 2020
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A dual-purpose metabolic switch
John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules. Read MoreMay 5, 2020
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The role of diet in esophageal cancer
New findings suggest that dietary calcium and magnesium affect the risk of esophageal cancer; if confirmed in interventional studies, they could inform dietary modifications to reduce the burden of this cancer. Read MoreMay 4, 2020
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EHRs, biobanks and Mendelian diseases
Electronic health records and biobanks can be effectively combined to detect and study Mendelian diseases such as cystic fibrosis. Read MoreApr 30, 2020
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Antibody finding raises hopes for Marburg, COVID-19 treatments
Monoclonal antibodies against Marburg virus — a more lethal cousin of the RNA virus that causes COVID-19 — may aid in the development of antibody "cocktails" to counter viral infection. Read MoreApr 30, 2020
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Transporter’s role in gut barrier
A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections. Read MoreApr 21, 2020
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Reducing stress in parents of children with autism
Parents of children with autism spectrum disorders benefited from the addition of mindfulness-based stress reduction to parent-implemented behavioral interventions. Read MoreApr 21, 2020
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‘Tuning’ cell shape for division
Dylan Burnette and colleagues have discovered that two forms of the molecular motor protein myosin have distinct roles in regulating cell shape during cell division. Read MoreApr 20, 2020
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Damage, disruption, delirium
New findings suggest that treatments that decrease oxidative damage might help with postoperative delirium that occurs in up to 30% of cardiac surgery patients. Read MoreApr 20, 2020
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Research team awarded $9 million to study extracellular RNA in colorectal cancer
A multidisciplinary team of investigators at Vanderbilt University and Vanderbilt University Medical Center has received a program project grant from the National Cancer Institute to explore extracellular RNA in colorectal cancer. Read MoreApr 15, 2020
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Study tracks genomics of lung tumor behavior
A study by Vanderbilt researchers has identified genomic alterations in early stage adenocarcinomas of the lung that may indicate whether the lesions develop into aggressive tumors. Read MoreApr 13, 2020