NIGMS

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders. Read More

Electronic medical records linked to DNA biobanks are a valid resource for defining and understanding the genetic factors that contribute to drug response. Read More

Vanderbilt researchers have discovered small molecules that turn off cancerous Ras signals in a new way. Read More

Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin. Read More

Using imaging data, Vanderbilt researchers discovered an association between a gene pair and brain changes in Alzheimer’s disease. Read More

by Denise Anthony (iStock) A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast?… Read More

Vanderbilt researchers have discovered that variation in the gene encoding the potassium channel GIRK1 plays a role in modulating human pain perception. Read More

The protein CK1 delays cell division to avoid the generation of defects that drive tumorigenesis. Read More

A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues. Read More

Using computational tools to search for the genetic basis of what makes us human, Vanderbilt Assistant Professor of Biomedical Informatics Tony Capra and colleagues at the University of California-San Francisco have identified promising candidate regions. Read More

Inhibitors of a signaling pathway that is critical to synovial sarcoma tumorigenesis may be useful treatments for this aggressive cancer. Read More

Vanderbilt researchers have identified a key regulator of cell division. Read More

Vanderbilt researchers are studying how mutations in the receptor for light, rhodopsin, cause light blindness. Read More

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug. Read More

New mass spectrometry imaging methods will enable studies of the distribution and identification of membrane proteins directly within tissues. Read More

A newly identified factor regulates blood vessel growth in colorectal tumors and could be a promising target for cancer therapies. Read More

A biomarker for oxidative stress is elevated in patients with both autism spectrum disorder and gastrointestinal dysfunction, suggesting opportunities for individualized approaches to clinical care. Read More

A motor protein that helps drive cell division may be a promising new target for cancer therapeutics. Read More

The new web application NetGestalt will allow investigators to simultaneously visualize different types of data for the same gene – such as mutation, expression and modification. Read More

Diseases associated with mutations and changes in expression of the protein caveolin may result from faulty trafficking of the protein to the cell surface. Read More