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DNA

Completing DNA synthesis

Oct. 21, 2019—James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.

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New method reveals how differences in the genetic “instruction booklet” between humans and Neanderthals influenced traits

Oct. 7, 2019—When it comes to our differences from Neanderthals, most of what we know comes from comparing fossils. But fossils can only tell us about bones and not whole living organisms. That’s changing thanks to a new paper from a team of genomics researchers at Vanderbilt, who have developed a first-of-its-kind computational method. Their approach uses...

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Genetic balancing act

Aug. 9, 2018—David Cortez and colleagues have found that a protein called RADX helps modulate a protein called RAD51 in order to make sure exactly the correct amount of DNA repair occurs.

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Study spots undiagnosed genetic diseases in EHR

Mar. 15, 2018—Patients diagnosed with heart failure, stroke, infertility and kidney failure could actually be suffering from rare and undiagnosed genetic diseases.

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Novel insights to antibiotic targets

Sep. 29, 2017—New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

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Deciphering potent DNA toxin’s secrets

Aug. 1, 2017—Vanderbilt researchers uncover the secret of the remarkable potency of the DNA toxin yatakemycin, which could someday be harnessed to fight cancer.

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New method for tapping vast plant pharmacopeia to make more effective drugs

Apr. 14, 2017—Geneticists have developed an effective new method for identifying the genes that produce the chemicals plants use to protect themselves from predators, which are an important natural drug source.

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Team identifies ‘switch’ involved in DNA replication  

Feb. 23, 2017—DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by a chemical “switch.”

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Saliva test for obesity risk

Jan. 24, 2017—“Epigenetic signatures” in DNA may present an opportunity for prevention of or early intervention in childhood obesity.

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DNA duplicator small enough to hold in your hand

Jan. 11, 2017—Imagine a “DNA photocopier” small enough to hold in your hand that could identify the bacteria or virus causing an infection even before the symptoms appear.

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DNA duplicator small enough to hold in your hand

Jan. 11, 2017—Vanderbilt engineers have developed a new method for duplicating DNA that makes devices small enough to hold in your hand that are capable of identifying infectious agents before symptoms appear.

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Rheumatoid subtypes explored by PheWAS

Oct. 7, 2016—A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis.

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