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DNA

Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Neanderthal DNA has subtle but significant impact on human traits

Feb. 11, 2016—The first study that directly compares Neanderthal DNA in the genomes of a significant population of adults of European ancestry with their clinical records confirms that this archaic genetic legacy has a subtle but significant impact on modern human biology.

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Faulty building blocks in DNA

Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

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Study helps clarify components of DNA ‘copy machine’

Nov. 12, 2015—Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

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New class of DNA repair enzyme discovered

Oct. 29, 2015—A new class of DNA repair enzyme has been discovered which demonstrates that a much broader range of damage can be removed from the double helix in ways that biologists did not think were possible.

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Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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Mitochondrial mutations not random

Nov. 25, 2013—A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues.

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VU ‘crosslinks’ study sheds light on chemical toxicity

Oct. 31, 2013—Vanderbilt researchers have characterized the chemical structures of a series of DNA-protein “crosslinks” that may lead to better ways to avoid the cancer-causing potential of environmental chemicals and prevent some drug toxicities.

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Untangling the tree of life

May. 15, 2013—Vanderbilt phylogeneticists examined the reasons why large-scale tree-of-life studies are producing contradictory results and have proposed a suite of novel techniques to resolve the contradictions.

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VANTAGE point

Apr. 25, 2013—Travis Clark, Ph.D., technical director of Sequencing in the VANTAGE core laboratories, shows a tour group how DNA fragments are loaded onto “flow cells” for reading by “next-generation” sequencing machines.

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Study tracks genes involved in heart rhythm disorders

Feb. 7, 2013—A team led by Vanderbilt University investigators has discovered two new genes — both coding for the signaling protein calmodulin — associated with severe early-onset disorders of heart rhythm.

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New view of DNA processing ‘hub’

Jan. 23, 2013—Structural studies reveal a new framework for understanding a central player in DNA processing.

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