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DNA

Rheumatoid subtypes explored by PheWAS

Oct. 7, 2016—A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis.

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Discovery of male-harming DNA mutation reinforces ‘mother’s curse’ hypothesis

Aug. 2, 2016—There is new evidence that the "mother’s curse" – the possibility that moms may transmit genes to their children that harm their sons but not their daughters – holds true in animals.

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When mitochondrial genes act up

Jul. 12, 2016—A team of Vanderbilt scientists have identified some of the methods that mutant mitochondrial DNA use to circumvent the molecular mechanisms that cells use to regulate mitochondrial activity.

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Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Neanderthal DNA has subtle but significant impact on human traits

Feb. 11, 2016—The first study that directly compares Neanderthal DNA in the genomes of a significant population of adults of European ancestry with their clinical records confirms that this archaic genetic legacy has a subtle but significant impact on modern human biology.

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Faulty building blocks in DNA

Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

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Study helps clarify components of DNA ‘copy machine’

Nov. 12, 2015—Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

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New class of DNA repair enzyme discovered

Oct. 29, 2015—A new class of DNA repair enzyme has been discovered which demonstrates that a much broader range of damage can be removed from the double helix in ways that biologists did not think were possible.

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Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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Mitochondrial mutations not random

Nov. 25, 2013—A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues.

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VU ‘crosslinks’ study sheds light on chemical toxicity

Oct. 31, 2013—Vanderbilt researchers have characterized the chemical structures of a series of DNA-protein “crosslinks” that may lead to better ways to avoid the cancer-causing potential of environmental chemicals and prevent some drug toxicities.

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Untangling the tree of life

May. 15, 2013—Vanderbilt phylogeneticists examined the reasons why large-scale tree-of-life studies are producing contradictory results and have proposed a suite of novel techniques to resolve the contradictions.

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